有限空间分辨率和时间分辨率对纳米通道中压力驱动流动的超分辨率粒子跟踪测速仪的影响

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2024-05-14 DOI:10.1007/s10404-024-02733-z
Minori Tanaka, Yo Saeki, Itsuo Hanasaki, Yutaka Kazoe
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引用次数: 0

摘要

随着纳米流体技术的发展,了解纳米空间中的流体行为变得非常重要。粒子跟踪是一种高效的方法,但在纳米空间中,它往往受到有限时间分辨率和有限空间分辨率的影响,前者会导致纳米粒子的布朗位移,后者则会降低纳米粒子图像的信噪比,这两个因素都会造成伪影。因此,在本研究中,我们基于朗格文方程给出的粒子动力学模拟了纳米粒子跟踪测速,以评估伪影。结果表明,在利用 60 纳米示踪纳米粒子的 400 纳米通道中测量压力驱动流动的速度分布时,需要高速(时间分辨率:Δt ≤ 360 µs)和超分辨率(空间分辨率:Δz ≤ 25 纳米)测量才能使误差小于 10%,而分辨率不足则会造成伪影,使速度分布与原始流动曲线相比变得扁平。我们小组开发的散焦纳米粒子跟踪测速仪在实验中验证了所提出的分辨率。正如模拟预测的那样,在较长的时间分辨率和较大的空间分辨率下,纳米通道中测得的纳米粒子速度分布显示出抛物线流动曲线,但由于伪影而变得扁平。与此相反,在建议范围内的测量分辨率下,成功获得了接近哈根-普瓦耶方程给出的速度分布曲线,这被认为是实际的流动曲线。这项工作为纳米级流动测量提供了指导,并将加速对纳米空间中特定传输现象的理解。
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Effect of finite spatial and temporal resolutions on super-resolution particle tracking velocimetry for pressure-driven flow in a nanochannel

With developments of nanofluidics, understanding the behavior of fluids confined in nanospaces becomes important. Particle tracking is an efficient approach, but in nanospaces, it often suffers from the finite temporal resolution, which causes the Brownian displacement of nanoparticles, and the finite spatial resolution due to the decreased signal-to-noise ratio of nanoparticle images, both of which are factors that can cause artifacts. Therefore, in the present study, we simulated nanoparticle tracking velocimetry based on the particle dynamics given by the Langevin equation to evaluate the artifacts. The results revealed that for measurement of the velocity distribution of pressure-driven flow in a 400 nm nanochannel utilizing 60 nm tracer nanoparticles, high-speed (temporal resolution: Δt ≤ 360 µs) and super-resolution (spatial resolution: Δz ≤ 25 nm) measurement is required for errors less than 10%, while insufficient resolution causes an artifact that results in a flattened velocity distribution compared with the original flow profile. The proposed resolutions were experimentally verified by defocusing nanoparticle tracking velocimetry developed by our group. As the simulation predicted, at longer temporal resolution and larger spatial resolution, the measured nanoparticle velocity distribution in the nanochannel indicated a parabolic flow profile but became flattened because of the artifacts. In contrast, at measurement resolutions within the proposed range, the velocity distribution close to the profile given by the Hagen-Poiseuille equation, which was considered to be the actual flow profile, was successfully obtained. This work provides a guideline for nanoscale flow measurements and will accelerate the understanding of specific transport phenomena in nanospaces.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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