临床医生对抑郁症的看法以及艾司西酞普兰在抑郁症治疗中的作用

Nilesh Shah M, Rajesh Kumar, Sathianathan R, Manushree Gupta, M. S, K. Kumar M
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摘要

背景:抑郁症是一种新出现的严重失调症,也是一个严重的公共卫生问题,常常不被人们发现。它与许多疾病相关。非传染性疾病和自杀率的增加使抑郁症的发病率上升。这些都会对患者的生活质量产生负面影响,并增加发病率和死亡率的负担。研究目的本研究旨在通过一套调查问卷收集印度临床医生的临床见解和专家意见,从而深入了解艾司西酞普兰在抑郁症治疗中的作用。研究方法2017年6月至10月期间,在印度主要城市的医生中开展了一项基于问卷的横断面研究,收集他们对当前药物疗法的经验和满意度以及艾司西酞普兰在抑郁症治疗中的作用的意见。研究采用了方便抽样法。向愿意参与研究的医生发送了名为 "CHEER(临床医生对抑郁症和艾司西酞普兰作用的看法)"的预试问卷手册。为此,医生们被要求填写这份调查问卷,并表达他们对抑郁症管理各个方面的看法。调查结果显示在 200 名临床医生中,共有 177 名来自印度各地的医生分享了他们的经验和观点。根据调查数据,58.19% 的临床医生表示,在他们的临床实践中,平均每月有超过 15 名患者被诊断为抑郁症。约 75% 的临床医生表示,与男性患者相比,女性患者的抑郁症发病率更高。报告显示,抑郁症在受过城市教育的患者中更为常见(47.11%)。抑郁症多见于 31-40 岁年龄组。约 58% 的临床医生表示,咨询与药物治疗同等重要。调查报告显示,90% 以上的临床医生倾向于将艾司西酞普兰作为治疗抑郁症的一线药物。在临床实践中,超过 87% 的临床医生更倾向于将艾司西酞普兰与氯硝西泮联合使用,以治疗焦虑抑郁症并发症。结论本调查报告显示,在 SSRIs 和其他抗抑郁药物中,大多数临床医生(85%)首选艾司西酞普兰治疗抑郁症。调查还显示,艾司西酞普兰的疗效更好,不良反应更少。
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Clinician’s Opinion on Depression and Role of Escitalopram in the Management of Depression
Background: Depression is an emerging severe disorder and a serious public health problem, which can often go undetected. It is associated with many disease conditions. Increase in non-communicable diseases, suicide rate, has made its incidence to increase. These will have a negative impact on patient’s quality of life and will increase the burden of morbidity and mortality. Objective: The aim of this study was to gain a deeper understanding of the role of escitalopram in the management of depression by collecting clinical insights and expert opinion from Indian clinicians through a set of questionnaire. Methodology: A cross sectional, questionnaire based study was conducted to collect opinion among doctors in the major Indian cities, about experience and satisfaction with current pharmacotherapy and role of escitalopram in the management of depression across India between June to October 2017. Convenient sampling method was used. The pretested questionnaire booklet titled CHEER (Clinicians Opinions on Depression and role of Escitalopram) study was sent to the doctors who were willing to participate. For this, physicians were requested to complete this survey and express their opinion towards the various aspect of managing depression. Results: Totally, 177 out of 200 clinicians shared their experiences and opinion from all over India. As per survey data, 58.19% of clinicians reported that in their clinical practice, on an average, more than 15 patients were diagnosed with depression in a month. Around 75% of clinicians say that incidence of depression was more common in the female when compared to the male patients. Reports showed that incidence of depression was more common in urban educated patients (47.11%). Depression was seen more commonly in the age group of 31-40 years. About 58% of clinicians reported that counselling was as important as pharmacotherapy. The survey report suggested that more than 90% of clinicians prefer escitalopram as a first-line therapeutic agent for treating depression. More than 87% of clinicians prefer escitalopram in combination with clonazepam to treat co-morbidity of anxiety depression in their clinical practise. Conclusion: The present survey report suggested that majority of clinicians (85%) preferred escitalopram to treat depression among the SSRIs and other antidepressants agents. Survey also showed that escitalopram has better efficacy and lesser adverse effects.
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