Mwelwa Chibuye, Daniel R Mende, Rene Spijker, Michelo Simuyandi, Chaluma C Luchen, Samuel Bosomprah, Roma Chilengi, Constance Schultsz, Vanessa C Harris
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At the phylum level, inconsistent associations with stunting were observed for Bacillota, Pseudomonadota, and Bacteroidota phyla. No single genus was associated with stunted children across all 14 studies, and some associations were incongruent by specific genera. Nonetheless, stunting was associated with an abundance of pathobionts that could drive inflammation, such as Escherichia/Shigella and Campylobacter, and a reduction of butyrate producers, including Faecalibacterium, Megasphera, Blautia, and increased Ruminoccoccus. An abundance of taxa thought to originate in the oropharynx was also reported in duodenal and fecal samples of stunted children, while metabolic pathways, including purine and pyrimidine biosynthesis, vitamin B biosynthesis, and carbohydrate and amino acid degradation pathways, predicted linear growth. 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引用次数: 0
摘要
儿童发育迟缓与认知发展受损以及感染、发病和死亡风险增加有关。肠道微生物群的组成可能与发育迟缓的发病机制有关。我们系统地回顾并综合了采用高通量基因组测序方法对低收入国家 5 岁以下发育迟缓儿童与非发育迟缓儿童肠道微生物组进行特征描述的研究数据。我们纳入了来自亚洲、非洲和南美洲的 14 项研究。大多数研究未报告α多样性存在任何显著差异,而在报告β多样性的七项研究中,有四项研究观察到发育迟缓儿童的β多样性显著较高。在门一级,芽孢杆菌科、假单胞菌科和类菌科与发育迟缓的关系不一致。在所有 14 项研究中,没有一个属与儿童发育迟缓有关,有些属与特定属的关系也不一致。尽管如此,发育迟缓与可引起炎症的病原菌(如埃希氏/志贺氏菌和弯曲杆菌)的大量存在以及丁酸生产者(包括粪杆菌、巨球菌、布劳氏菌)的减少和反刍球菌的增加有关。在发育迟缓儿童的十二指肠和粪便样本中,还发现了大量被认为起源于口咽部的类群,而代谢途径,包括嘌呤和嘧啶的生物合成、维生素 B 的生物合成以及碳水化合物和氨基酸的降解途径,则预测了线性生长。目前的研究表明,与非发育迟缓儿童相比,发育迟缓儿童可能具有不同的微生物模式,这可能是发育迟缓的发病机理之一。
Systematic review of associations between gut microbiome composition and stunting in under-five children.
Childhood stunting is associated with impaired cognitive development and increased risk of infections, morbidity, and mortality. The composition of the enteric microbiota may contribute to the pathogenesis of stunting. We systematically reviewed and synthesized data from studies using high-throughput genomic sequencing methods to characterize the gut microbiome in stunted versus non-stunted children under 5 years in LMICs. We included 14 studies from Asia, Africa, and South America. Most studies did not report any significant differences in the alpha diversity, while a significantly higher beta diversity was observed in stunted children in four out of seven studies that reported beta diversity. At the phylum level, inconsistent associations with stunting were observed for Bacillota, Pseudomonadota, and Bacteroidota phyla. No single genus was associated with stunted children across all 14 studies, and some associations were incongruent by specific genera. Nonetheless, stunting was associated with an abundance of pathobionts that could drive inflammation, such as Escherichia/Shigella and Campylobacter, and a reduction of butyrate producers, including Faecalibacterium, Megasphera, Blautia, and increased Ruminoccoccus. An abundance of taxa thought to originate in the oropharynx was also reported in duodenal and fecal samples of stunted children, while metabolic pathways, including purine and pyrimidine biosynthesis, vitamin B biosynthesis, and carbohydrate and amino acid degradation pathways, predicted linear growth. Current studies show that stunted children can have distinct microbial patterns compared to non-stunted children, which could contribute to the pathogenesis of stunting.
期刊介绍:
npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.