白色念珠菌和光滑念珠菌:全球优先病原体。

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-06-04 DOI:10.1128/mmbr.00021-23
Myrto Katsipoulaki, Mark H T Stappers, Dhara Malavia-Jones, Sascha Brunke, Bernhard Hube, Neil A R Gow
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引用次数: 0

摘要

摘要在过去十年中,由念珠菌引起的感染发病率大幅上升,这主要是由于易感人群数量的增加。最近,世界卫生组织公布了第一份真菌病原体优先列表,将念珠菌列为中度、高度和严重优先类别。这篇综述综述了我们对其中两种念珠菌--白念珠菌和光滑念珠菌--的了解和最新进展。其中,白念珠菌是全球最常见的念珠菌血症病因,被列为重大优先病原体。格拉布氏念珠菌被认为是高度优先病原体,近年来已成为念珠菌血症越来越重要的病因。在许多地区,它现在是念珠菌病的第二大常见致病菌。尽管它们之间存在差异和系统发育上的分歧,但作为人类的病原体和共生菌,它们都很成功。这两种病菌都能引起多种感染,从浅表感染到可能致命的全身感染。虽然它们在某些感染策略(包括组织粘附和入侵)上有相似之处,但在生物学、与免疫细胞的相互作用、宿主损伤策略和新陈代谢适应性等关键方面却有很大不同。在此,我们将就它们的生物学、流行病学、共生和致病生活方式、与免疫系统的相互作用以及抗真菌耐药性等关键方面发表见解。
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Candida albicans and Candida glabrata: global priority pathogens.

SUMMARYA significant increase in the incidence of Candida-mediated infections has been observed in the last decade, mainly due to rising numbers of susceptible individuals. Recently, the World Health Organization published its first fungal pathogen priority list, with Candida species listed in medium, high, and critical priority categories. This review is a synthesis of information and recent advances in our understanding of two of these species-Candida albicans and Candida glabrata. Of these, C. albicans is the most common cause of candidemia around the world and is categorized as a critical priority pathogen. C. glabrata is considered a high-priority pathogen and has become an increasingly important cause of candidemia in recent years. It is now the second most common causative agent of candidemia in many geographical regions. Despite their differences and phylogenetic divergence, they are successful as pathogens and commensals of humans. Both species can cause a broad variety of infections, ranging from superficial to potentially lethal systemic infections. While they share similarities in certain infection strategies, including tissue adhesion and invasion, they differ significantly in key aspects of their biology, interaction with immune cells, host damage strategies, and metabolic adaptations. Here we provide insights on key aspects of their biology, epidemiology, commensal and pathogenic lifestyles, interactions with the immune system, and antifungal resistance.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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