膀胱肿瘤微生物群与卡介苗反应

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-06-18 DOI:10.1038/s41585-024-00910-x
Louise Lloyd
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引用次数: 0

摘要

卡介苗治疗是治疗高分化中危和高危非肌层浸润性膀胱癌(NMIBC)的金标准疗法。然而,约有 30-40% 接受卡介苗治疗的患者会出现治疗失败,而且卡介苗的作用机制还不甚明了。因此,肿瘤微生物组在膀胱癌治疗反应中的作用越来越受到关注。现在,新的数据让我们深入了解了卡介苗应答者和卡介苗非应答者之间微生物组物种丰富度和多样性的差异,并确定了可能的机制途径。在回顾性分析中,对2012年至2018年期间收集的47份经尿道膀胱肿瘤切除术(TURBT)的档案福尔马林固定石蜡包埋(FFPE)组织样本和14份配对的根治性膀胱切除术标本进行了鉴定,并比较了卡介苗反应。所有患者至少接受过卡介苗诱导和六次灌注。应答者的定义是,在接受一个疗程的诱导治疗后,无论是否接受维持治疗,至少两年内无疾病证据--共确定了23例应答者。根据 AUA-SUO 指南,无应答者的定义是:进展为肌肉浸润性膀胱癌、持续存在高级别 T1 疾病或在完成卡介苗诱导治疗后 3 个月内进展为高级别 T1 疾病、尽管接受了两个周期的卡介苗诱导治疗,但持续存在高级别 TA 疾病或原位癌--共确定了 24 名无应答者,其中 14 人有配对的根治性膀胱切除术样本。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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