{"title":"从秋刀鱼果实中提取的两种新葫芦烷类三萜皂甙","authors":"","doi":"10.1080/10286020.2024.2364908","DOIUrl":null,"url":null,"abstract":"<div><div>Two new cucurbitane-type triterpenoid saponins, 2,20<em>β</em>,22<em>β</em>-trihydroxy-16<em>α</em>,23(<em>R</em>)-epoxycucurbita-1,5,24-triene-3,11-dione 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), 2,20<em>β</em>,22<em>α</em>-trihydroxy-16<em>α</em>,23(<em>S</em>)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>2</strong>) were isolated from the fruit of <em>Citrullus colocynthis</em> (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 <em>μ</em>M against paracetamol-induced HepG2 cell damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1320-1327"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis\",\"authors\":\"\",\"doi\":\"10.1080/10286020.2024.2364908\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new cucurbitane-type triterpenoid saponins, 2,20<em>β</em>,22<em>β</em>-trihydroxy-16<em>α</em>,23(<em>R</em>)-epoxycucurbita-1,5,24-triene-3,11-dione 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), 2,20<em>β</em>,22<em>α</em>-trihydroxy-16<em>α</em>,23(<em>S</em>)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>2</strong>) were isolated from the fruit of <em>Citrullus colocynthis</em> (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 <em>μ</em>M against paracetamol-induced HepG2 cell damage.</div></div>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\"26 11\",\"pages\":\"Pages 1320-1327\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1028602024000870\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602024000870","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis
Two new cucurbitane-type triterpenoid saponins, 2,20β,22β-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-β-D-glucopyranoside (1), 2,20β,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-β-D-glucopyranoside (2) were isolated from the fruit of Citrullus colocynthis (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 μM against paracetamol-induced HepG2 cell damage.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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