纤毛运输复合蛋白核功能的进化轨迹。

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2024-09-26 Epub Date: 2024-07-12 DOI:10.1128/mmbr.00006-24
Alexander Ewerling, Helen Louise May-Simera
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引用次数: 0

摘要

摘要纤毛和细胞核是真核生物最后一个共同祖先的两个决定性特征。在真核生物进化的早期,这些结构是通过一个共同的膜衣祖先--原衣壳蛋白--的多样化进化而来的。在纤毛中,这种蛋白质复合体的后代进化成了纤毛内运输复合体和 BBSome 的一部分,而在细胞核中,则是通过在核膜上招募类似原衣壳的蛋白质来形成选择性核孔复合体,从而获得了选择性。最近的研究表明,越来越多的蛋白质在各自细胞器的蛋白质组之间共享,目前还不清楚纤毛转运蛋白如何获得核功能,反之亦然。纤毛蛋白的核功能在今天仍然可以观察到,并且仍然与了解纤毛疾病背后的疾病机制相关。在这项工作中,我们回顾了纤毛和细胞核及其各自定义蛋白的进化史,并将当前的知识整合到早期真核生物进化的理论中。我们假设了这两个区室共同进化的情景,它符合当前的真核生物进化模型,解释了纤毛蛋白和核蛋白如何获得其双重功能。
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Evolutionary trajectory for nuclear functions of ciliary transport complex proteins.

SUMMARYCilia and the nucleus were two defining features of the last eukaryotic common ancestor. In early eukaryotic evolution, these structures evolved through the diversification of a common membrane-coating ancestor, the protocoatomer. While in cilia, the descendants of this protein complex evolved into parts of the intraflagellar transport complexes and BBSome, the nucleus gained its selectivity by recruiting protocoatomer-like proteins to the nuclear envelope to form the selective nuclear pore complexes. Recent studies show a growing number of proteins shared between the proteomes of the respective organelles, and it is currently unknown how ciliary transport proteins could acquire nuclear functions and vice versa. The nuclear functions of ciliary proteins are still observable today and remain relevant for the understanding of the disease mechanisms behind ciliopathies. In this work, we review the evolutionary history of cilia and nucleus and their respective defining proteins and integrate current knowledge into theories for early eukaryotic evolution. We postulate a scenario where both compartments co-evolved and that fits current models of eukaryotic evolution, explaining how ciliary proteins and nucleoporins acquired their dual functions.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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