关于脑部疾病,苍蝇能给我们什么启示?

Abigail D. Wilson, Simon A. Lowe, James E. C. Jepson, Gabriel Aughey
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摘要

影响大脑的疾病是导致全球残疾的主要原因之一。许多医生和科学家都在努力研究这些疾病是如何产生的,以及如何治疗。不幸的是,大脑是一个极其复杂的器官,因此这一目标非常具有挑战性。简化这一挑战的方法之一是研究更简单的大脑。例如,人脑的脑细胞数量是果蝇大脑的十万倍,但其工作方式却大同小异。虽然果蝇看起来与人类非常不同,但我们仍然有很多共同点。例如,我们都有控制身体运动的大脑。科学家们正在利用果蝇的大脑来研究影响人类患者的各种脑部疾病。果蝇大脑可以用来了解疾病是如何发生的,甚至还可以用来测试药物以发现新药。本文概述了科学家如何利用果蝇来帮助了解和治疗脑部疾病。
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What can flies teach us about brain diseases?
Diseases that affect the brain are one of the leading causes of disability worldwide. Many doctors and scientists are trying to work out how these diseases arise and how they can be treated. Unfortunately, the brain is an extremely complicated organ, so this goal is very challenging. One way of simplifying this challenge is to look at simpler brains. For example, a human brain has about 100,000 times more brain cells than a fruit fly brain, but it works in a similar way. Although a fruit fly may seem very different from a human, we still have a lot in common. For example, we both have brains that control how we move our bodies. Scientists are using fruit fly brains to study a wide range of brain diseases that affect human patients. Fly brains can be used to understand how a disease happens, and they can even be used to test drugs to discover new medicines. This article gives an overview of how scientists are using flies to help understand and treat brain disorders.
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