治疗溃疡性结肠炎的自然方法:临床前和临床研究的证据。

IF 4.8 3区 化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-07-30 DOI:10.1007/s13659-024-00463-x
Rudra Narayan Subudhi, Neelam Poonia, Dilpreet Singh, Vimal Arora
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引用次数: 0

摘要

溃疡性结肠炎(UC)是一种反复发作的自身免疫性疾病,其特点是大肠下部粘膜持续发炎。水杨酸盐、皮质类固醇激素和免疫抑制剂等传统治疗方法往往具有严重的副作用、有限的生物利用度以及耐药性的产生,从而影响了其治疗效果。因此,当务之急是探索自然疗法,作为治疗多发性硬化症的安全替代疗法。目前,约有 40% 的 UC 患者通过天然成分获得缓解,这有助于减少毒副作用并维持临床缓解。本综述旨在总结临床前和临床证据,证明各种天然物质在预防 UC 方面的功效。这些天然物质包括植物提取物、精油、营养保健品和植物化学物质。此外,我们还将深入研究这些新型草药的保护和治疗作用的潜在机制。总之,本综述将探讨治疗 UC 的天然疗法的有效性,揭示其临床前和临床研究结果及其治疗作用背后的机制。这些替代疗法为改善治疗效果和减少副作用带来了希望,使人们摆脱这种具有挑战性的自身免疫疾病的困扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations

Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining of the lower part of the large intestine. Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, and the development of drug resistance, which hampers their therapeutic effectiveness. Therefore, it is imperative to explore natural strategies as safe and alternative treatments for UC. Currently, around 40% of UC patients find relief through natural constituents, which can help reduce toxic side effects and maintain clinical remission. This review aims to provide a summary of both preclinical and clinical evidence supporting the efficacy of various natural substances in the prophylaxis of UC. These natural options include plant extracts, essential oils, nutraceuticals, and phytochemicals. Furthermore, we will delve into the potential mechanisms that underlie the protective and curative actions of these novel herbal agents. In summary, this review will explore the effectiveness of natural remedies for UC, shedding light on their preclinical and clinical findings and the mechanisms behind their therapeutic actions. These alternatives offer hope for improved treatment outcomes and reduced side effects for individuals suffering from this challenging autoimmune condition.

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来源期刊
Natural Products and Bioprospecting
Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-
CiteScore
8.30
自引率
2.10%
发文量
39
审稿时长
13 weeks
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