用于微创给药的磁性结构启发微针阵列

Maher Amer, Christina Fisher, Georgia Small, Blake Bullock, Vero Salinas, Jaden Langford
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摘要

微针阵列(MNA)是一种很有前途的给药工具,旨在降低侵入性和疼痛。为了降低 MNA 的穿透力,对许多设计参数进行了优化。其中一个重要参数是微针宽度,因为它直接关系到穿透皮肤所需的力,宽度越小,所需的穿透力就越低。这项研究探索了在 MNA 设计中使用具有负泊松比的辅助结构。在插入针头时,针头受到的挤压会导致其径向尺寸缩小,而不是像正泊松比结构那样增大。这项研究表明,由于使用了辅助结构而不是传统的非辅助结构,穿刺力降低了 25%。研究采用了增材制造和软成型技术来制造 MNA。这项研究强调了在 MNA 设计中使用辅助结构的可行性。
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Auxetic Structure Inspired Microneedle Arrays for Minimally Invasive Drug Delivery
Microneedle Arrays (MNAs) are promising drug delivery tools aimed at lowering invasiveness and pain. Many design parameters are optimized to lower penetration force in MNAs. An important parameter is the microneedle width as that relates directly to the force required to penetrate the skin, the lower the width the lower the penetration force needed. This research explored the use of auxetic structures known for having negative Poisson ratios in the design of MNAs. As the needles are inserted the compression on the needles causes their radial dimension to shrink instead of increasing as in positive Poisson ration structures. This study has shown a 25% reduction in penetration force due to using an auxetic structure instead of a conventional non-auxetic structure. The research employs additive manufacturing and soft molding to fabricate the MNAs. This study emphasizes the viability of using auxetic structures in MNA design.
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