Impact of Metabolic Associated Fatty Liver Disease on Health-Related Quality of Life

Introduction : Metabolic associated fatty liver disease (MAFLD), the nomenclature major benefit is the shift towards a diagnosis of inclusion based on the presence of metabolic dysfunction. MAFLD has also been associated with impaired health-related quality of life (HRQOL). Aim : to assess the impact of MAFLD & degree of hepatic steatosis and fibrosis on patients’ HRQOL applying the SF-36 Questionnaire. Methods : This cross sectional study was carried out on 250 adult who were subdivided into 2 groups, Group I (GI) comprised 150 consecutive patients with MAFLD while Group II (GII) comprised 100 apparently healthy subjects. Both studied groups had completed the short form-36 (SF-36) questionnaire. Results : The mean age among cases group was 43.6 ±10.5 years & females were the predominant. There was a highly statistical significance negative correlation between body mass index (BMI) and all domains of SF-36 questionnaire among GI. Scores of all scales of SF-36 were significantly lower in GI compared to GII). Hepatic steatosis grades with in GI according to CAP values were S1(17.3%), S2(37.3%) and S3(45.3). scores of all scales of SF-36 were significantly lower in S3 patients compared to S2 & S1(P value<0.001). Fibrosis stages within GI according to LSM values were F0(44.7%), F1(32.7%), F2(12.7%), F3(6.7%) & F4(3.3%). scores of all scales of SF-36 were significantly lower in F4 patients compared to F3, F2, F1 & F0(P value<0.001). Conclusion : HRQOL is