肠道微生物群失调与 COVID-19 中色氨酸代谢改变和炎症反应失调有关。

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-08-01 DOI:10.1038/s41522-024-00538-0
Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E Sander, Yang Li, Jennifer A Kirwan, Sofia K Forslund, Bastian Opitz
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引用次数: 0

摘要

COVID-19 的临床病程多变,往往难以预测。为了验证疾病进展和炎症反应与微生物组和代谢组改变有关的假设,我们分析了住院的 COVID-19 患者和未感染对照组重复样本的元基因组、代谢组、细胞因子和转录组图谱,并利用临床信息和事后混杂因素分析进行了分析。严重的COVID-19与肠道有益微生物的减少有关,而口咽微生物群紊乱主要与抗生素的使用有关。COVID-19严重程度还与犬尿氨酸血浆浓度升高以及其他几种色氨酸代谢物、溶血磷脂酰胆碱和次级胆汁酸水平降低有关。此外,各种色氨酸代谢物浓度的降低与粪杆菌的减少有关,色氨酸的减少和犬尿氨酸的增加与炎症细胞因子的分泌增加有关。总之,我们的研究确定了相关微生物组和代谢组的改变是导致严重 COVID-19 炎症失调的潜在因素。
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Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.

The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome, cytokine, and transcriptome profiles of repeated samples from hospitalized COVID-19 patients and uninfected controls, and leveraged clinical information and post-hoc confounder analysis. Severe COVID-19 was associated with a depletion of beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance was mainly linked to antibiotic use. COVID-19 severity was also associated with enhanced plasma concentrations of kynurenine and reduced levels of several other tryptophan metabolites, lysophosphatidylcholines, and secondary bile acids. Moreover, reduced concentrations of various tryptophan metabolites were associated with depletion of Faecalibacterium, and tryptophan decrease and kynurenine increase were linked to enhanced production of inflammatory cytokines. Collectively, our study identifies correlated microbiome and metabolome alterations as a potential contributor to inflammatory dysregulation in severe COVID-19.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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