Milana Kendrisic, Jonas Nienhaus, Vladislav Agafonov, Matthias Salas, Quang Nguyen, Hemma Resch, Clemens Vass, Wolfgang Drexler, Tilman Schmoll, Rainer A. Leitgeb
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引用次数: 0
摘要
近来,低成本光学相干断层成像技术日益兴起,因为人们越来越需要在诊所以外的地方普遍使用 OCT 设备。创建低成本 SS-OCT 系统的主要障碍之一是激光器的价格。在这项工作中,我们研究了不同调谐参数(如频率、占空比、调制曲线、温度)对之前提出的 850 nm 低成本单模热调谐垂直腔表面发射激光器(VCSEL)光源带宽的影响。通过优化参数,该激光器在 50 kHz A 扫描速率下实现了 10.2 nm 的调谐带宽。此外,我们还展示了利用定制的基于 VCSEL 的低成本 OCT 设备首次对前后节段进行三维渲染的体积扫描。在基于深度学习的去噪技术的帮助下,单次扫描中的噪声得以大幅降低。此外,通过研究相位稳定性,我们发现扫描之间的相位稳定性会随着调制频率的上升而增加,从而使辅助干涉仪变得过时。因此,该系统的 50 kHz 调谐方案也适用于 OCT 血管造影等功能扩展。
Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography
Low-cost optical coherence tomography has recently emerged as a growing field due to the increased need for general availability of OCT devices outside of the clinics. One of the main obstacles in creating low-cost SS-OCT systems is the price of the laser. In this work, we study the influence of different tuning parameters (e.g., frequency, duty cycle, modulation curve, temperature) on the resulting bandwidth of the previously proposed low-cost single-mode thermally-tunable vertical-cavity surface-emitting laser (VCSEL) source at 850 nm. With optimal parameters, the laser achieves a tuning bandwidth of 10.2 nm at a 50 kHz A-scan rate. In addition, we show the first 3D rendered volume scans of both anterior and posterior segment using a custom VCSEL-based low-cost OCT setup. With the help of deep-learning-based denoising, it was possible to critically reduce the noise in single scans. Moreover, by investigating the phase stability, it became apparent that phase stability between sweeps increases with rising modulation frequencies, making the auxiliary interferometer obsolete. Thus, the system’s 50 kHz tuning regimen is also suitable for functional extensions such as OCT angiography.
期刊介绍:
The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including:
Tissue optics and spectroscopy
Novel microscopies
Optical coherence tomography
Diffuse and fluorescence tomography
Photoacoustic and multimodal imaging
Molecular imaging and therapies
Nanophotonic biosensing
Optical biophysics/photobiology
Microfluidic optical devices
Vision research.