功能化萘啶的绿色合成和细胞毒性活性。

IF 3.9 2区 化学 Q2 CHEMISTRY, APPLIED Molecular Diversity Pub Date : 2024-08-08 DOI:10.1007/s11030-024-10929-2
Somayeh Soleimani-Amiri, Mahsa Hojjati, Zinatossadat Hossaini
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引用次数: 0

摘要

本研究采用 SiO2/Fe3O4 作为可重复使用的催化剂,在室温下利用水溶液中的苯甲醛、丙二腈、苯酚和乙炔酯,以高收率多组分合成了 1,8-萘啶。利用 MTT 试验,在体外评估了所有生成化合物对癌细胞株(MCF-7 和 A549)和正常细胞株(BEAS-2B)的细胞毒性。结果发现,最有效的细胞毒剂是衍生物 5h,它具有类似多柔比星的选择性。另一方面,化合物 5c 可被视为与多柔比星具有更大选择性的等效分子。此外,本研究还调查了 1,8-萘啶羧酸盐的抗氧化作用,以及本研究中进行的其他研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Green synthesis and cytotoxic activity of functionalized naphthyridine.

A multicomponent synthesis of 1,8-naphthyridine with high yields utilizing benzaldehydes, malononitrile, phenol, and acetylenic esters in aqueous solution at room temperature in the presence of SiO2/Fe3O4 as a reusable catalyst is reported. Using the MTT test, the cytotoxic properties of all the produced compounds were assessed in vitro against cancer cell lines (MCF-7 and A549) and normal cell lines (BEAS-2B). It was discovered that the most effective cytotoxic agent, doxorubicin-like in its lack of selectivity, was the derivative 5h. On the other hand, the compound 5c might be regarded as an equipotent molecule with greater selectivity in relation to doxorubicin. Also, this study investigates the antioxidant effects of 1,8-naphthyridine carboxylates, along with other studies conducted in this study.

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来源期刊
Molecular Diversity
Molecular Diversity 化学-化学综合
CiteScore
7.30
自引率
7.90%
发文量
219
审稿时长
2.7 months
期刊介绍: Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;
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