2022年9月至2023年6月加拿大不列颠哥伦比亚省(B.C.)和育空地区高致病性禽流感H5N1支系2.3.4.4b的描述性流行病学和系统发生学分析。

IF 8.4 2区 医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-09-22 DOI:10.1080/22221751.2024.2392667
Shannon L Russell, Cassandra L Andrew, Kevin C Yang, Michelle Coombe, Glenna McGregor, Tony Redford, Agatha N Jassem, James E A Zlosnik, Jolene Giacinti, Kevin S Kuchinski, John L Palmer, John R Tyson, Chris Fjell, Megan Willie, Megan V Ross, Maeve Winchester, Laurie Wilson, Yohannes Berhane, Caeley Thacker, N Jane Harms, Catherine Soos, Theresa Burns, Natalie Prystajecky, Chelsea Himsworth
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引用次数: 0

摘要

利用来自野生动物和家禽的监测数据,描述了2022年9月至2023年6月期间高致病性禽流感(HPAI)2.3.4.4b支系在加拿大不列颠哥伦比亚省(B.C.)和育空地区的传播情况,并与该地区在病毒首次传入后于2022年4月至8月爆发的第一 "波 "进行了比较。虽然 "第二波 "中高致病性禽流感阳性家禽养殖场和野生动物样本的数量更多,但病例更集中于不列颠哥伦比亚省西南部,最常受影响的物种也有所不同,这可能是由于该地区涌入了大量越冬水禽。检测到八个高致病性禽流感基因群,代表七个基因型和两个洲际病毒入侵,各群的相对丰度在不同波次之间存在显著差异。系统发生学数据表明,野鸟向家禽和哺乳动物传播病毒的事件有多次发生,但不能排除在农场之间和哺乳动物之间传播的可能性。
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Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023.

Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from September 2022 - June 2023 compared to the first "wave" of the outbreak in this region, which occurred April - August 2022, after the initial viral introduction. Although the number of HPAI-positive poultry farms and wildlife samples was greater in "Wave 2", cases were more tightly clustered in southwestern B.C. and the most commonly affected species differed, likely due to an influx of overwintering waterfowl in the area. Eight HPAI genetic clusters, representing seven genotypes and two inter-continental viral incursions, were detected, with significant variation in the relative abundance of each cluster between the waves. Phylogenetic data suggests multiple spillover events from wild birds to poultry and mammals but could not rule out transmission among farms and among mammals.

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来源期刊
Emerging Microbes & Infections
Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY
CiteScore
26.20
自引率
2.30%
发文量
276
审稿时长
20 weeks
期刊介绍: Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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