饮食与微生物组之间的相互作用可促进脊髓损伤后肠道神经系统的恢复能力。

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-08-29 DOI:10.1038/s41522-024-00556-y
Adam M Hamilton, Lisa Blackmer-Raynolds, Yaqing Li, Sean D Kelly, Nardos Kebede, Anna E Williams, Jianjun Chang, Sandra M Garraway, Shanthi Srinivasan, Timothy R Sampson
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引用次数: 0

摘要

脊髓损伤(SCI)会导致许多全身性功能障碍,包括肠道运动障碍和肠神经系统(ENS)萎缩。肠神经系统在受到干扰后有能力恢复,但肠道病变仍然存在。有新的证据表明 SCI 会引起肠道微生物组组成的改变,因此我们假设微生物组的调节有助于伤后肠道的恢复。在这里,我们展示了使用膳食纤维菊粉进行干预可预防 SCI 诱导的小鼠 ENS 萎缩和运动障碍。虽然 SCI 相关微生物群和特定的损伤敏感性肠道微生物不足以调节损伤后的肠道运动障碍,但用微生物衍生的短链脂肪酸(SCFA)代谢物进行干预可防止损伤小鼠的 ENS 功能障碍。值得注意的是,菊粉介导的恢复能力依赖于IL-10信号传导,凸显了饮食-微生物-免疫轴对促进损伤后耳鼻咽喉神经系统恢复能力的关键作用。总之,我们证明饮食和微生物衍生信号对创伤性脊柱损伤后 ENS 的存活有明显影响,为揭示 SCI 引起的神经源性肠道的病因机制和未来疗法奠定了基础。
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Diet-microbiome interactions promote enteric nervous system resilience following spinal cord injury.

Spinal cord injury (SCI) results in numerous systemic dysfunctions, including intestinal dysmotility and enteric nervous system (ENS) atrophy. The ENS has capacity to recover following perturbation, yet intestinal pathologies persist. With emerging evidence demonstrating SCI-induced alterations to gut microbiome composition, we hypothesized that microbiome modulation contributes to post-injury enteric recovery. Here, we show that intervention with the dietary fiber, inulin, prevents SCI-induced ENS atrophy and dysmotility in mice. While SCI-associated microbiomes and specific injury-sensitive gut microbes are not sufficient to modulate intestinal dysmotility after injury, intervention with microbially-derived short-chain fatty acid (SCFA) metabolites prevents ENS dysfunctions in injured mice. Notably, inulin-mediated resilience is dependent on IL-10 signaling, highlighting a critical diet-microbiome-immune axis that promotes ENS resilience post-injury. Overall, we demonstrate that diet and microbially-derived signals distinctly impact ENS survival after traumatic spinal injury and represent a foundation to uncover etiological mechanisms and future therapeutics for SCI-induced neurogenic bowel.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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