[外周血淋巴细胞亚群与前列腺癌的预后有关]。

Q4 Medicine 中华男科学杂志 Pub Date : 2024-04-01

Fei Mao, Chao Yang, Lu Ji

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引用次数: 0

摘要

目的：探讨外周淋巴细胞亚群与 PCa 患者生存率之间的关系：探讨外周淋巴细胞亚群与 PCa 患者生存期之间的关系：采用 Kaplan-Meier 曲线和对数秩检验比较了 100 例不同淋巴细胞水平的 PCa 患者的总生存期（OS）和无进展生存期（PFS）。同时，我们通过单变量和多变量考克斯回归分析研究了预后因素，并通过流式细胞术统计了外周淋巴细胞亚群：淋巴细胞水平高（≥747/μl）、CD3+T细胞（≥528/μl）、CD4+T细胞（≥315/μl）、CD8+T细胞（≥226/μl）、B细胞（≥105/μl）和NK细胞（≥168/μl）的PCa患者的OS和PFS均明显延长（P＜0.001）。单变量和多变量Cox回归分析表明，CD4+T细胞≤315/μl是PCa预后不良的独立因素（HR=12.58，95% CI：3.00-52.73）：结论：外周淋巴细胞亚群绝对计数的降低与PCa的不良预后有关。

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[Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer].

Objective: To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.

Methods: Using the Kaplan-Meier curve and log-rank test, we compared the overall survival (OS) and progression-free survival (PFS) of 100 PCa patients with different levels of lymphocytes. Meanwhile, we investigated the prognostic factors by univariate and multivariate Cox regression analyses, and counted the peripheral lymphocyte subsets by flow cytometry.

Results: Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes (≥747/μl), CD3+T cells (≥528/μl), CD4+T cells (≥315/μl), CD8+T cells (≥226/μl), B cells (≥105/μl) and NK cells (≥168/μl)(P < 0.001). Univariate and multivariate Cox regression analyses indicated that CD4+T cells ≤ 315/μl was an independent factor for the poor prognosis of PCa (HR=12.58, 95% CI: 3.00－52.73).

Conclusion: Decreased absolute count of peripheral lymphocyte subsets is associated with the poor prognosis of PCa.

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