基因-代谢物联系标志着储存的红细胞质量

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL Analytical Chemistry Pub Date : 2024-09-03 DOI:10.1016/j.cmet.2024.08.004

Changhan Chen, Wuping Liu, Yang Xia

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引用次数: 0

摘要

长期以来，输注红细胞（RBC）一直是治疗多种疾病的基石，但在影响 RBC 储存质量和输注效果的生物和遗传因素之间还存在知识空白。在本期《细胞代谢》杂志上，Nemkov 等人介绍了一种多组学方法，用于识别新鲜和储存的 RBC 中的基因代谢物关联。这些发现为确定储存红细胞的质量、改善其储存和输血效果提供了潜在的策略。

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Gene-metabolite linkage marks stored red blood cell quality

Red blood cell (RBC) transfusion has long been the cornerstone of treatment for multiple diseases, but there is a knowledge gap between biological and genetic factors impacting RBC storage quality and transfusion efficacy. In this issue of Cell Metabolism, Nemkov et al. present a multiomics approach to identify gene-metabolite associations in fresh and stored RBCs. These findings provide potential strategies to mark the quality of stored RBCs and improve their storage and transfusion performance.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.