口腔鳞状细胞癌的风险因素,特别强调阿月浑子的使用及其与临床病理参数和复发的关系。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.1155/2024/9725822
Atif Ali Hashmi, Ghazala Mudassir, Khushbakht Rashid, Umair Arshad Malik, Shamail Zia, Fazail Zia, Muhammad Irfan
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引用次数: 0

摘要

简介口腔鳞状细胞癌(OSCC)是头颈部癌症中最常见的一种,死亡率很高,尤其是在东南亚国家。咀嚼阿月浑子、吸烟和饮酒是口腔鳞状细胞癌最常见的风险因素。咀嚼阿月浑子在巴基斯坦非常普遍,也是导致 OSCC 病例增加的原因之一。本研究旨在确定咀嚼槟榔与 OSCC 的各种临床病理特征之间的关系,并进一步评估 OSCC 的临床病理参数与肿瘤复发之间的关系:该研究使用了2018年至2022年5年间在巴基斯坦卡拉奇利亚卡特国立医院切除的228例OSCC患者的数据。从医院档案中收集了临床病理数据,并确定了各种风险因素与临床病理参数之间的关联:男性患者较多(77.2%),最常见的年龄组是结论组:在我们的研究人群中,与亚麻仁相关的 OSCC 与预后不良和复发有关。此外,OSCC复发与各种临床病理参数有关,如肿瘤体积较大、DOI较高和结节转移。
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Risk Factors of Oral Squamous Cell Carcinoma with Special Emphasis on Areca Nut Usage and Its Association with Clinicopathological Parameters and Recurrence.

Introduction: Oral squamous cell carcinoma (OSCC) is the most prevalent type of head and neck cancer and is associated with high mortality, particularly in Southeast Asian countries. Areca nut usage, smoking, and alcohol consumption are the most common risk factors for OSCC. Areca nut chewing is highly prevalent in Pakistan and has been attributed to an increase in OSCC cases. This study aimed to determine the association between areca nut usage and various clinicopathological features of OSCC and further evaluate the association of clinicopathological parameters of OSCC with tumor recurrence.

Materials and methods: The study was conducted using the data of 228 patients with OSCC resected at Liaquat National Hospital, Karachi, Pakistan, over 5 years between 2018 and 2022. Clinicopathological data were collected from hospital archives, and associations between various risk factors and clinicopathological parameters were determined.

Results: Males were more commonly affected (77.2%), and the most common age group was <50 years (54.4%). Areca nut usage was reported in 59.6% of cases, and the buccal mucosa was the most common site (62.7%). Areca nut usage was significantly associated with male gender, greater tumor size, greater depth of invasion (DOI), higher tumor stage, nodal stage, presence of perineural invasion (PNI), and recurrence. In addition, multivariate analysis revealed that OSCC recurrence was significantly associated with older age, larger tumor size and DOI, nodal metastasis, and areca nut usage.

Conclusion: Areca nut-related OSCCs were associated with poor prognosis and recurrence in our study population. Furthermore, OSCC recurrence was associated with various clinicopathological parameters, such as larger tumor size, a higher DOI, and nodal metastasis.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
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