TldR：TnpB 从转座子核酶到 RNA 引导的转录调节器的进化转变

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-09-19 DOI:10.1016/j.tim.2024.09.004

Prarthana Mohanraju, Wen Y. Wu

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引用次数: 0

摘要

TnpB 蛋白是转座子编码的核酶，参与转座子 DNA 的传播。Wiegand 等人发现了一类新的 TnpB 衍生蛋白，称为 TnpB-like 核酸酶致死抑制因子（TldRs），它们作为 RNA 引导的转录调节因子，靶向保守的启动子区域。在肠杆菌科细菌中，噬菌体利用 TldRs 和邻近的噬菌体基因来调节宿主鞭毛的组装。

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TldR: TnpB’s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators

TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcriptional regulators targeting conserved promoter regions. In Enterobacteriaceae, bacteriophages use TldRs and an adjacent phage gene to modulate host flagellar assembly.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.