工程预制牙本质具有排列整齐的分层矿化胶原纤维束,可促进生物根再生。

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.1177/20417314241280961
Lei Hu, Dongmei Cheng, Xin Yuan, Zhenhua Gao, Qiao Yi, Bin Zhao, Fulan Wei, Junji Xu, Zhipeng Fan, Yi Liu, Xiumei Wang, Fuzhai Cui, Chunmei Zhang, Jinsong Wang, Songlin Wang
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引用次数: 0

摘要

干细胞介导的生物根再生是一种替代性牙齿替换策略;然而,具有独特牙本质结构的生理功能生物根再生仍然具有挑战性。本研究确定了胶原纤维束的不同排列方式,这些排列方式说明了牙本质、骨水泥和牙槽骨之间的层次结构差异。因此,我们制作了一种 "工程前牙本质",它是一种模仿胶原蛋白(MC)支架的牙本质分层结构,具有排列整齐的分层矿化胶原纤维束。研究结果表明,与羟基磷灰石磷酸三钙(HA/TCP)相比,它在促进裸鼠和微型猪牙髓干细胞(DPSC)和牙周韧带干细胞(PDLSC)片的生物根再生方面具有更强的效果。MC组的成功率也高于HA/TCP组(分别为67%和33%)。总之,分层仿牙本质支架可以提高生物牙根的再生能力,为牙齿再生提供了一种前景广阔的策略。
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Engineered pre-dentin with well-aligned hierarchical mineralized collagen fibril bundles promote bio-root regeneration.

Stem cell-mediated bio-root regeneration is an alternative tooth replacement strategy; however, physiologically functional bio-root regeneration with distinctive dentin structure remains challenging. In this study, the distinct arrangements of collagen fibril bundles were identified that account for hierarchical structural differences between dentin, cementum, and alveolar bone. Thus, an "engineered pre-dentin" was fabricated, which was a dentin hierarchical structure mimicking collagen (MC) scaffold, with well-aligned hierarchical mineralized collagen fibril bundles. The results revealed that it has a stronger effect on promoting biological root regeneration in nude mice and miniature pigs with dental pulp stem cell (DPSC) and periodontal ligament stem cell (PDLSC) sheets compared to hydroxyapatite tricalcium phosphate (HA/TCP). The success rate in the MC group was also higher than that in the HA/TCP group (67% and 33%, respectively). In conclusion, the hierarchical dentin-mimicking scaffold can enhance the regeneration of bio-roots, which provides a promising strategy for tooth regeneration.

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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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