{"title":"乙炔二羧酸二甲酯存在下取代二硝基乙腈与异喹啉反应的新化学变化","authors":"Е. А. Yurtaeva, A. G. Tyrkov","doi":"10.1134/S1070428024070169","DOIUrl":null,"url":null,"abstract":"<p>The 1,3-dipolar cycloaddition reaction of substituted dinitroacetonitriles with isoquinoline in the presence of acetylene dicarboxylic acid dimethyl ester results in the formation of a mixture of diastereomeric dimethyl 2-dinitromethyl-1,1b<i>H</i>-pyrimido[2,1-<i>a</i>]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Chemical Transformation of Substituted Dinitroacetonitrile in the Reaction with Isoquinoline in the Presence of Acetylene Dicarboxylic Acid Dimethyl Ester\",\"authors\":\"Е. А. Yurtaeva, A. G. Tyrkov\",\"doi\":\"10.1134/S1070428024070169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The 1,3-dipolar cycloaddition reaction of substituted dinitroacetonitriles with isoquinoline in the presence of acetylene dicarboxylic acid dimethyl ester results in the formation of a mixture of diastereomeric dimethyl 2-dinitromethyl-1,1b<i>H</i>-pyrimido[2,1-<i>a</i>]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.</p>\",\"PeriodicalId\":766,\"journal\":{\"name\":\"Russian Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070428024070169\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024070169","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
New Chemical Transformation of Substituted Dinitroacetonitrile in the Reaction with Isoquinoline in the Presence of Acetylene Dicarboxylic Acid Dimethyl Ester
The 1,3-dipolar cycloaddition reaction of substituted dinitroacetonitriles with isoquinoline in the presence of acetylene dicarboxylic acid dimethyl ester results in the formation of a mixture of diastereomeric dimethyl 2-dinitromethyl-1,1bH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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