脑-肠轴:神经退行性疾病发展过程中的沟通机制和微生物组作为神经保护因子的作用:文献综述。

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024019
Mgr Natalia Białoń, Dr Hab N O Zdr Dariusz Górka, Mgr Mikołaj Górka
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引用次数: 0

摘要

研究脑-肠轴及其对认知功能和神经退行性疾病发展的影响,是研究人员非常感兴趣的一个适时课题。本综述总结了肠道与大脑交流的基本机制。然后,我们将讨论肠道微生物群作为神经保护因子在神经退行性疾病中的作用。肠道微生物群在维持机体平衡、塑造人体免疫系统和大脑正常功能方面极其重要。肠道微生物群会影响神经可塑性、突触生成和神经元再生过程。本综述旨在解释阿尔茨海默氏症、帕金森氏症和多发性硬化症患者肠道微生物菌群组成的变化。在压力、抑郁或自闭症谱系发育过程中,肠道微生物菌群的组成也会出现异常。此外,还介绍了关于精神生物补充剂在缓解神经退行性疾病症状方面的新发现。
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The brain-gut axis: communication mechanisms and the role of the microbiome as a neuroprotective factor in the development of neurodegenerative diseases: A literature overview.

The study of the brain-gut axis and its impact on cognitive function and in the development of neurodegenerative diseases is a very timely topic of interest to researchers. This review summarizes information on the basic mechanisms of gut-brain communication. We then discuss the roles of the gut microbiome as a neuroprotective factor in neurodegeneration. The gut microbiota is extremely important in maintaining the body's homeostasis, shaping the human immune system and the proper functioning of the brain. The intestinal microflora affects the processes of neuroplasticity, synaptogenesis, and neuronal regeneration. This review aims to explain changes in the composition of the bacterial population of the intestinal microflora among patients with Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Abnormalities in gut microflora composition are also noted in stress, depression, or autism spectrum development. New observations on psychobiotic supplementation in alleviating the symptoms of neurodegenerative diseases are also presented.

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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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