用于电子束治疗的黄铜网状注射器的特性。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-10-25 DOI:10.1088/2057-1976/ad87f7
Sara N Lim, James J Sohn, Slade J Klawikowski, John P Hayes, Eric Donnelly, Indra J Das
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引用次数: 0

摘要

对于接近皮肤表面或在皮肤表面的目标,通常需要注射栓剂,然而,在复杂表面上注射标准栓剂可能会导致空气间隙,从而影响剂量测定。黄铜网状栓剂(RPD 公司,明尼苏达州阿尔伯特维尔)的设计符合患者表面,减少了空气间隙。在标准多能量 LINAC 上使用 10×10 平方厘米的涂抹器,研究了黄铜网状栓剂在 6、9 和 12 MeV 电子下的剂量特性。使用 Markus® 平行板电离室(34045 型,PTW Freiburg,德国)、热释光探测器(TLD)和 EBRT 胶片,在固体水和 3D 打印树脂乳房模型(Anycubic Photon MonoX,深圳,中国)上测量了黄铜网下的栓剂当量和百分比深度剂量 (PDD),并进行了表面剂量测量。获得表面剂量测量结果后,将其与 Pinnacle3 治疗计划系统(TPS,16.2,Koninklijke Philips N.V.)计算的剂量进行比较。黄铜网下的表面剂量测量结果显示,黄铜网下的剂量始终高于未使用栓剂时的剂量,这证实黄铜网可将表面的 PDD 提高到 dmax 剂量的约 94%,具体取决于入射电子能量。对于 6 MeV 电子,这一增加相当于使用 ~7.2 mm 水当量栓剂;对于 9 MeV 电子,相当于使用 ~3.6 mm 水当量栓剂;对于 12 MeV 电子,相当于使用 ~2.2 mm 水当量栓剂。TPS 结果显示与体内测量结果非常接近,证实了黄铜网作为电子辐照栓的潜力,但前提是正确模拟胀气效应。适当的实施可以简化处理过程,并提高纯电子计划中的栓剂一致性。
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Characterization of brass mesh bolus for electron beam therapy.

Purpose. Bolus is often required for targets close to or on skin surface, however, standard bolus on complex surfaces can result in air gaps that compromise dosimetry. Brass mesh boluses (RPD, Inc., Albertville, MN) are designed to conform to the patient's surface and reduce air gaps. While they have been well characterized for their use with photons, minimal characterization exists in literature for their use with electrons.Methods and materials.Dosimetric characteristics of brass mesh bolus was investigated for use with 6, 9 and 12 MeV electrons using a 10 × 10 cm2applicator on standard multi-energy LINAC. Measurements for bolus equivalence and percentage depth doses (PDDs) under brass mesh, as well as surface dose measurements were performed on solid water and a 3D printed resin breast phantom (Anycubic Photon MonoX, Shenzhen, China) using Markus®parallel-plate ionization chamber (Model 34045, PTW Freiburg, Germany), thermoluminescent detectors (TLD) and EBRT film. After obtaining surface dose measurements, these were compared to dose calculated on the Pinnacle3 treatment planning system (TPS, 16.2, Koninklijke Philips N.V.).Results. Measurements of surface dose under brass mesh showed consistently higher dose than without bolus, confirming that brass mesh can increase the PDD at surface up to ∼ 94% of dose at dmax, depending on incident electron energy. This increase is equivalent to using ∼ 7.2 mm water equivalent bolus for 6 MeV, ∼ 3.6 mm for 9 MeV and ∼ 2.2 mm bolus for 12 MeV electrons. TPS results showed close agreement within-vivomeasurements, confirming the potential for brass mesh as bolus for electron irradiation, provided blousing effect is correctly modelled.Conclusions. To increase electron surface dose, a brass mesh can be used with equivalent effect of water-density bolus varying with electron energy. Proper implementation could allow for ease of treatment, as well as increase bolus conformality in electron-only plans.

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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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