用于功能性食品开发和太空任务的虾青素生物合成。

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-10-20 DOI:10.1080/07388551.2024.2410364
Xiulan Xie, Moyu Zhong, Xinxin Huang, Xinrui Yuan, Nasser Mahna, Cassamo Ussemane Mussagy, Maozhi Ren
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引用次数: 0

摘要

虾青素(AXT)是一种天然类胡萝卜素,具有很强的抗氧化和抗衰老作用,可以减少紫外线对细胞和 DNA 的损伤,刺激免疫系统,改善心血管疾病的预后。尽管 AXT 在营养保健品、化妆品、水产养殖和制药行业有着广泛的应用,但由于天然来源稀缺、生产效率低和要求高,AXT 的工业生产和应用受到了阻碍。本综述比较了不同天然来源的 AXT 的质量差异,评估了在不同底盘生物中表达 AXT 的上游程序,并研究了基于合成生物学和细胞工厂的天然 AXT 工业生产策略。合成生物学是重新编程植物或微生物以生产 AXT 的一种前景广阔的新策略。此外,利用细胞工厂进行的基因工程还超出了陆地应用的范围,因为它可能有助于在太空探索和移民过程中实现人类健康的长期可持续性。本综述为从微藻 Haematococcuspluvialis 中高效、准确地进行 AXT 基因工程提供了理论依据,为今后 AXT 及其他生物代谢物的生物制造研究提供了宝贵的参考。
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Astaxanthin biosynthesis for functional food development and space missions.

Astaxanthin (AXT), a natural carotenoid, has strong antioxidant and anti-ageing effects and can reduce ultraviolet light-induced damage to cells and DNA, stimulate the immune system, and improve cardiovascular disease prognosis. Despite its wide applications in the: nutraceutical, cosmetic, aquaculture, and pharmaceutical industries, AXT industrial production and application are hindered by natural source scarcity, low production efficiency, and high requirements. This review compares the qualitative differences of AXT derived from different natural sources, evaluates the upstream procedures for AXT expression in different chassis organisms, and investigates synthetic biology- and cell factory-based strategies for the industrial production of natural AXT. Synthetic biology is a promising novel strategy for reprogramming plants or microorganisms to produce AXT. Additionally, genetic engineering using cell factories extends beyond terrestrial applications, as it may contribute to the long-term sustainability of human health during space exploration and migration endeavors. This review provides a theoretical basis for the efficient and accurate genetic engineering of AXT from the microalga Haematococcuspluvialis, providing a valuable reference for future research on the biomanufacturing of AXT and other biological metabolites.

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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
期刊最新文献
Recent advances and biotechnological applications of RNA metabolism in plant chloroplasts and mitochondria. APETALA2/ethylene-responsive factors in higher plant and their roles in regulation of plant stress response. Fashion meets science: how advanced breeding approaches could revolutionize the textile industry. Insight into recent advances in microalgae biogranulation in wastewater treatment. Advances in Vibrio-related infection management: an integrated technology approach for aquaculture and human health.
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