膝关节镜手术后关节内麻醉利多卡因和甲基强的松龙与单用甲基强的松龙的镇痛效果对比。

IF 3.4 Q2 CHEMISTRY, MEDICINAL ADMET and DMPK Pub Date : 2024-08-03 eCollection Date: 2024-01-01 DOI:10.5599/admet.2412
Wahid Mohammed Hassan, Anas Amer Mohammad
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引用次数: 0

摘要

背景:膝关节镜是一种广泛使用的骨科手术,以微创方法著称,与传统的开放式手术相比,恢复时间更快,术后不适感更少。然而,控制术后疼痛仍然是患者护理和满意度的一个重要方面。本研究的主要目的是探讨患者人口统计学特征(年龄、性别、体重指数)与术后早期结果(包括疼痛、理疗和行走)之间的关系:方法:随机数据收集,对两组患者进行临床试验研究。患者分为利多卡因 1 % 16 毫升 + 甲基强的松龙 160 毫克 4 毫升)组和(仅甲基强的松龙 160 毫克 4 毫升)组。两组的所有患者均在术后第 1 天、第 3 天和第 15 天接受了有关年龄、性别、体重指数和疼痛的询问。所有患者均在术后第二、第三和第四天接受了物理治疗测试。术后第三、四、五天进行步行测试:结果:术后疼痛缓解程度和物理治疗开始时间存在显著差异。治疗组与恢复指标(如术后不同天数的疼痛程度和活动能力)之间存在显著关联。结论:利多卡因和甲基强的松龙可改善膝关节镜手术患者的术后疼痛缓解和功能恢复,大多数患者在术后早期疼痛减轻(早期物理治疗),并加快恢复行走(发病率降低)。仅服用甲基强的松龙的患者恢复较慢。年龄、性别和体重指数会影响术后疼痛和行走能力,但不会影响物理治疗时间,这说明术后治疗需要个性化方法。
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Analgesic effects of intraarticular anaesthetic lidocaine and methylprednisolone versus methylprednisolone alone following knee arthroscopy.

Background: Knee arthroscopy is a widely practiced orthopaedic procedure known for its minimally invasive approach, allowing quicker recovery times and less postoperative discomfort than traditional open surgeries. However, managing postoperative pain remains a critical aspect of patient care and satisfaction. The main objective of this research is to examine the relationships between patient demographics (age, gender, BMI) and early postoperative outcomes, including pain, physiotherapy, and walking.

Method: Randomized data collection, clinical trial study of 2 groups of patients. The patients were split into lidocaine 1 % 16 ml + methylprednisolone 160 mg 4 ml) and (methylprednisolone only 160 mg 4 ml) groups. All patients in both groups were queried about age, gender, BMI, and pain on the first, third, and 15th days following surgery. All patients were tested for physiotherapy on the second, third, and fourth postop days. After surgery, walking was tested on the third, fourth, and fifth days.

Results: Significant differences in postoperative pain relief and physiotherapy initiation times were observed. There are notable associations between treatment groups and recovery metrics, such as pain levels and mobility on various days' post-surgery. Significant demographic influences (age, gender, BMI) on recovery outcomes are observed, particularly in walking and pain at day 15 post-operation.

Conclusion: lidocaine and methylprednisolone improve postoperative pain relief and functional recovery in knee arthroscopy patients, with most experiencing reduced pain early post-surgery (early physiotherapy) and an expedited return to walking (decreased morbidity). Patients taking just methylprednisolone recovered slower. Age, gender, and BMI affected pain and walking abilities post-operation but not physiotherapy time, underscoring the personalised approach needed in postoperative treatment.

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来源期刊
ADMET and DMPK
ADMET and DMPK Multiple-
CiteScore
4.40
自引率
0.00%
发文量
22
审稿时长
4 weeks
期刊介绍: ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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