犬类快速肝脏移植手术:初步研究

IF 1.4 Q3 SURGERY Surgery open science Pub Date : 2024-10-29 DOI:10.1016/j.sopen.2024.10.006
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引用次数: 0

摘要

背景目前在无肝期植入肝脏移植物的方法较为复杂。方法将 24 只犬随机分为两组:改良正位肝移植组(M-OLT,n = 12)和对照组(n = 12)。所有动物都被随机分配到供体组或受体组。在M-OLT组中,受体接受改良技术的正位肝移植;在对照组中,受体接受不经静脉旁路的传统植入技术的OLT。比较了两组供体和受体的特征。结果 所有受者都成功接受了肝移植手术。两组受者在性别、体重和供肝冷缺血时间方面没有明显差异。然而,与对照组相比,M-OLT 组受者的手术时间更短、术中失血量更少、无肝期更短、血管闭塞时间更短以及热缺血时间更短(均为 p <0.05)。两组肝移植术后均未发现吻合口漏或狭窄。结论这种改良技术在犬肝移植中安全可行,可大大简化无肝期的肝移植植入手术。
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Rapid liver graft implantation in canine: A preliminary study

Background

The current method for liver graft implantation during the anhepatic phase is complex. Therefore, this study aimed to introduce a modified orthotopic liver transplantation (OLT) technique with major vascular reconstruction using cuff technique to simplify the process of liver graft implantation during the anhepatic phase.

Methods

Twenty-four canines were randomly assigned to two groups: the modified orthotopic liver transplantation group (M-OLT, n = 12) and the control group (n = 12). All animals were randomly assigned to the donor or recipient groups. The recipients received orthotopic liver transplantation using a modified technique in the M-OLT group, and OLT using traditional implantation technique without venovenous bypass was performed in the control group. The donor and recipient characteristics were compared between the two groups. Vascular anastomotic patency was evaluated using angiography immediately and one week after surgery.

Results

All recipients underwent successful liver transplantation. There were no significant differences between the two groups in terms of sex, body weight, or cold ischemia time of the donor liver. However, recipients in the M-OLT group had a shorter operation time, less intraoperative blood loss, shorter anhepatic phase, shorter vascular occlusion time, and shorter warm ischemia time than that in the control group (all p < 0.05). No anastomotic leakage or stenosis was detected in either group after liver transplantation. One recipient in the M-OLT group and three in the control group died within one week of transplantation.

Conclusions

This modified technique is safe and feasible for canine liver transplantation and can significantly simplify liver graft implantation procedures during the anhepatic period.
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来源期刊
CiteScore
1.30
自引率
0.00%
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审稿时长
66 days
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