2-Aminothiazole 衍生物的设计、合成、杀菌活性和分子对接研究

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090252

Y. Zhang, Y. Deng, X. Lan, Y. Lu, D. Zhao, W. Wang, L. Chen, Z. Yan

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引用次数: 0

摘要

为了获得具有更强抗真菌活性的酰胺类化合物，研究人员采用组合化学技术合成了十二种 2-氨基噻唑衍生物。利用 1H NMR、13C NMR、ESI-MS 和元素分析等多种技术对新合成的化合物进行了表征。值得注意的是，化合物 11b 不仅对硬菌有很高的抑制率，而且还具有一定的抗癌作用。分子对接分析为该化合物如何实现其抗真菌效果提供了科学依据。

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Design, Synthesis, Fungicidal Activity, and Molecular Docking Study of 2-Aminothiazole Derivatives

In order to obtain amide compounds with enhanced antifungal activity, twelve 2-aminothiazole derivatives were synthesized using combinatorial chemistry techniques. The newly synthesized compounds were characterized by using various techniques such as ¹H NMR, ¹³C NMR, ESI-MS, and elemental analysis. Notably, compound 11b not only exhibited a high inhibitory rate against Sclerotinia sclerotiorum but also possessed certain anticancer effects. Molecular docking analysis provided a scientific basis for how this compound achieves its antifungal effects.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.