穿越突变迷宫：巨噬细胞重编程的致癌驱动指南

IF 25.5 1区医学 Q1 IMMUNOLOGY Immunity Pub Date : 2024-11-12 DOI:10.1016/j.immuni.2024.10.007

Ziyi Li, Ankur Sharma

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引用次数: 0

摘要

致癌突变和解剖位置共同影响肿瘤内免疫环境的机制尚不十分清楚。在本期《免疫》杂志上，Ross等人的研究表明，H3.3K27M弥漫中线胶质瘤（DMGs）富含疾病相关髓系细胞（DAMs）。以髓系细胞为靶点的策略能将DAMs重新编程为一种平衡状态，减少髓系细胞对肿瘤的浸润，并延长生存期。

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Navigating the mutation maze: An oncogenic driver’s guide to macrophage reprogramming

The mechanisms by which oncogenic mutations and anatomical locations work together to influence the immune environment within tumors are not well understood. In this issue of Immunity, Ross et al. show that H3.3K27M diffuse midline gliomas (DMGs) are enriched with disease-associated myeloid cells (DAMs). Myeloid-targeted strategies reprogram DAMs to a homeostatic state, reduce myeloid infiltration into tumors, and prolong survival.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.