A CT-based radiomics analyses for differentiating drug‑resistant and drug-sensitive pulmonary tuberculosis.

Background: To explore the value of computed tomography based radiomics in the differential diagnosis of drug-sensitive and drug-resistant pulmonary tuberculosis.

Methods: The clinical and computed tomography image data of 177 patients who were diagnosed with pulmonary tuberculosis through sputum culture and completed drug-susceptibility testing from April 2018 to December 2020 at the Second Hospital of Nanjing were retrospectively analyzed. Patients with drug-resistant pulmonary tuberculosis (n = 78) and drug-sensitive pulmonary tuberculosis (n = 99) were randomly divided into a training set (n = 124) and a validation set (n = 53) at a ratio of 7:3. Regions of interest were drawn to delineate the lesions and radiomics features were extracted from non-contrast computed tomography images. A radiomics signature based on the valuable radiomics features was constructed and a radiomics score was calculated. Demographic data, clinical symptoms, laboratory results and computed tomography imaging characteristics were evaluated to establish a clinical model. Combined with the Rad-score and clinical factors, a radiomics-clinical model nomogram was constructed.

Results: Thirteen features were used to construct the radiomics signature. The radiomics signature showed good discrimination in the training set (area under the curve (AUC), 0.891; 95% confidence interval (CI), 0.832-0.951) and the validation set (AUC, 0.803; 95% CI, 0.674-0.932). In the clinical model, the AUC of the training set was 0.780(95% CI, 0.700-0.859), while the AUC of the validation set was 0.692 (95% CI, 0.546-0.839). The radiomics-clinical model showed good calibration and discrimination in the training set (AUC, 0.932;95% CI, 0.888-0.977) and the validation set (AUC, 0.841; 95% CI, 0.719-0.962).

Conclusions: Simple radiomics signature is of great value in differentiating drug-sensitive and drug-resistant pulmonary tuberculosis patients. The radiomics-clinical model nomogram showed good predictive, which may help clinicians formulate precise treatments.