{"title":"从红树林源真菌青霉 GXIMD 03101 中分离出的一种新的环状七肽--Cadophorin C。","authors":"Jia-Li He, Xiao-Dong Jiang, Yu-Man Gan, Xin-Jian Qu, Xiang-Xi Yi, Yong-Hong Liu, Cheng-Hai Gao, Meng Bai","doi":"10.1080/14786419.2024.2425796","DOIUrl":null,"url":null,"abstract":"<p><p>One new cyclic heptapeptide, cadophorin C (<b>1</b>), and one known analogue cadophorin B (<b>2</b>) were isolated from the mangrove-derived fungus <i>Penicillium</i> sp. GXIMD 03101 from the mangrove <i>Acanthus ilicifolius</i> L. The chemical structure of <b>1</b> was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values. Compounds <b>1</b> and <b>2</b> were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. The results showed that compounds <b>1</b> and <b>2</b> have weak activity against <i>Vibrio harveyi</i> with MIC values of 3.12 and 12.5 μg/mL, respectively. Compounds <b>1</b> and <b>2</b> have significant inhibitory activity against BPH with IC<sub>50</sub> values of 2.62 and 2.23 μM, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus <i>Penicillium</i> sp. GXIMD 03101.\",\"authors\":\"Jia-Li He, Xiao-Dong Jiang, Yu-Man Gan, Xin-Jian Qu, Xiang-Xi Yi, Yong-Hong Liu, Cheng-Hai Gao, Meng Bai\",\"doi\":\"10.1080/14786419.2024.2425796\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>One new cyclic heptapeptide, cadophorin C (<b>1</b>), and one known analogue cadophorin B (<b>2</b>) were isolated from the mangrove-derived fungus <i>Penicillium</i> sp. GXIMD 03101 from the mangrove <i>Acanthus ilicifolius</i> L. The chemical structure of <b>1</b> was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values. Compounds <b>1</b> and <b>2</b> were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. The results showed that compounds <b>1</b> and <b>2</b> have weak activity against <i>Vibrio harveyi</i> with MIC values of 3.12 and 12.5 μg/mL, respectively. Compounds <b>1</b> and <b>2</b> have significant inhibitory activity against BPH with IC<sub>50</sub> values of 2.62 and 2.23 μM, respectively.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2425796\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2425796","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus Penicillium sp. GXIMD 03101.
One new cyclic heptapeptide, cadophorin C (1), and one known analogue cadophorin B (2) were isolated from the mangrove-derived fungus Penicillium sp. GXIMD 03101 from the mangrove Acanthus ilicifolius L. The chemical structure of 1 was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values. Compounds 1 and 2 were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. The results showed that compounds 1 and 2 have weak activity against Vibrio harveyi with MIC values of 3.12 and 12.5 μg/mL, respectively. Compounds 1 and 2 have significant inhibitory activity against BPH with IC50 values of 2.62 and 2.23 μM, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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