Karen D Bernal-Contreras, Montserrat Berrospe-Alfaro, Regina López de Cárdenas-Rojo, Martha H Ramos-Ostos, Misael Uribe, Iván López-Méndez, Eva Juárez-Hernández
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Liver steatosis was evaluated by controlled attenuation parameter, and patients were classified into five groups according to BMI, presence of MASLD, and metabolic characteristics: <25 kg/m<sup>2</sup> non-MASLD; <25 kg/m<sup>2</sup>-MASLD; Overweight-MASLD; Metabolically Healthy Obese (MHO)-MASLD; and Metabolically Unhealthy Obese (MUO)-MASLD. BC was assessed by bioelectrical impedance and a Bioimpedance Vectorial Analysis (BIVA) was carried out. Differences in BC were analyzed by a One-Way ANOVA test. Univariate and multivariate analyses were performed for factors associated with abnormal BC.</p><p><strong>Results: </strong>A total of 316 patients were included. 59% (<i>n</i> = 189) were male, with a mean age of 49 ± 10 years. Fat% significantly higher according to BMI was not different between BMI <25 kg/m<sup>2</sup>-MASLD and Overweight-MASLD groups. Skeletal muscle mass (SMM) was significantly lower in obesity groups with respect to overweight and normal weight groups (<i>p</i> < 0.05); however, no differences were observed in the post-hoc analysis. Extracellular Water/Intracellular Water ratio was significantly higher in the MHO-MASLD group and MUO-MASLD group compared with the BMI <25 kg/m<sup>2</sup> non-MASLD group and with the BMI <25 kg/m<sup>2</sup>-MASLD group. Abnormal Waist Circumference (WC) and liver steatosis were independent factors associated with abnormal BC.</p><p><strong>Conclusion: </strong>BC in MASLD patients varies according to BMI increase; changes could be explained by loss of SMM and not necessarily by the presence of metabolic abnormalities. 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Fat% significantly higher according to BMI was not different between BMI <25 kg/m<sup>2</sup>-MASLD and Overweight-MASLD groups. Skeletal muscle mass (SMM) was significantly lower in obesity groups with respect to overweight and normal weight groups (<i>p</i> < 0.05); however, no differences were observed in the post-hoc analysis. Extracellular Water/Intracellular Water ratio was significantly higher in the MHO-MASLD group and MUO-MASLD group compared with the BMI <25 kg/m<sup>2</sup> non-MASLD group and with the BMI <25 kg/m<sup>2</sup>-MASLD group. Abnormal Waist Circumference (WC) and liver steatosis were independent factors associated with abnormal BC.</p><p><strong>Conclusion: </strong>BC in MASLD patients varies according to BMI increase; changes could be explained by loss of SMM and not necessarily by the presence of metabolic abnormalities. 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引用次数: 0
摘要
背景：虽然身体成分（BC）与代谢功能障碍相关性脂肪肝（MASLD）有关，但几乎没有证据表明MASLD患者的BC与体重指数（BMI）存在差异。本研究旨在确定 MASLD 患者在体重指数和代谢合并症方面的 BC 差异：这是一项横断面研究，研究对象为参加体检的患者。根据 BMI、是否患有 MASLD 以及代谢特征将患者分为五组：2 非 MASLD；2-MASLD；超重-MASLD；代谢健康肥胖（MHO）-MASLD；代谢不健康肥胖（MUO）-MASLD。通过生物电阻抗评估 BC，并进行生物阻抗矢量分析（BIVA）。BC 差异通过单向方差分析检验进行分析。对 BC 异常的相关因素进行了单变量和多变量分析：结果：共纳入 316 名患者。59%（n = 189）为男性，平均年龄为 49 ± 10 岁。BMI 2-MASLD 组和超重-MASLD 组的脂肪率明显高于 BMI 2-MASLD 组，但两者之间没有差异。与超重组和正常体重组相比，肥胖组的骨骼肌质量（SMM）明显较低（P 2 非 MASLD 组和 BMI 2-MASLD 组）。腰围（WC）异常和肝脏脂肪变性是与 BC 异常相关的独立因素：结论：MASLD 患者的 BC 随 BMI 的增加而变化；变化的原因可能是 SMM 的丧失，而不一定是代谢异常的存在。高腹围和脂肪变性是与 BC 改变相关的独立因素。
Body composition differences in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.
Background: Although body composition (BC) has been associated with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), there is little evidence of differences in BC in patients with MASLD regarding body mass index (BMI). The aim of this study was to determine differences in BC in terms of BMI and metabolic comorbidities in patients with MASLD.
Materials and methods: It is a cross-sectional study with patients who attended the check-up unit. Liver steatosis was evaluated by controlled attenuation parameter, and patients were classified into five groups according to BMI, presence of MASLD, and metabolic characteristics: <25 kg/m2 non-MASLD; <25 kg/m2-MASLD; Overweight-MASLD; Metabolically Healthy Obese (MHO)-MASLD; and Metabolically Unhealthy Obese (MUO)-MASLD. BC was assessed by bioelectrical impedance and a Bioimpedance Vectorial Analysis (BIVA) was carried out. Differences in BC were analyzed by a One-Way ANOVA test. Univariate and multivariate analyses were performed for factors associated with abnormal BC.
Results: A total of 316 patients were included. 59% (n = 189) were male, with a mean age of 49 ± 10 years. Fat% significantly higher according to BMI was not different between BMI <25 kg/m2-MASLD and Overweight-MASLD groups. Skeletal muscle mass (SMM) was significantly lower in obesity groups with respect to overweight and normal weight groups (p < 0.05); however, no differences were observed in the post-hoc analysis. Extracellular Water/Intracellular Water ratio was significantly higher in the MHO-MASLD group and MUO-MASLD group compared with the BMI <25 kg/m2 non-MASLD group and with the BMI <25 kg/m2-MASLD group. Abnormal Waist Circumference (WC) and liver steatosis were independent factors associated with abnormal BC.
Conclusion: BC in MASLD patients varies according to BMI increase; changes could be explained by loss of SMM and not necessarily by the presence of metabolic abnormalities. High WC and the presence of steatosis are independent factors associated with altered BC.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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