{"title":"Talarindigotin A：一种细胞毒性靛红衍生物，来自红树林内生真菌 Talaromyces amestolkiae SCNU-F0041。","authors":"Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long","doi":"10.1080/10286020.2024.2428228","DOIUrl":null,"url":null,"abstract":"<p><p>A new indigotin alkaloid, named talarindigotin A (<b>1</b>), along with the analogue 5H, 6H-quinindolin-11-one (<b>2</b>) were isolated from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <b>1</b> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041.\",\"authors\":\"Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long\",\"doi\":\"10.1080/10286020.2024.2428228\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A new indigotin alkaloid, named talarindigotin A (<b>1</b>), along with the analogue 5H, 6H-quinindolin-11-one (<b>2</b>) were isolated from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <b>1</b> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2024.2428228\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2428228","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041.
A new indigotin alkaloid, named talarindigotin A (1), along with the analogue 5H, 6H-quinindolin-11-one (2) were isolated from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound 1 showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC50 values ranging from 2.08 to 4.58 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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