电子束疗法中用于注射的高兹材料研究

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-12-20 DOI:10.1088/2057-1976/ad9c7c
Indra J Das, Ahtesham U Khan, Sara Lim, Poonam Yadav, Eric Donnelley, Bharat B Mittal
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引用次数: 0

摘要

目的/目的:电子束常用于浅表肿瘤。然而,由于电子束的特性,表面剂量是规定剂量的75-95%,这取决于束流能量,因此需要放置丸来增加表面剂量。各种类型的丸剂在诊所中常用,每种丸剂都有其独特的局限性。大多数丸状装置不符合皮肤轮廓,并产生气隙,已知会产生剂量扰动,产生热点和冷点。布状高z材料;研究了钨(Z=74)和铋(Z=83)浸渍在硅胶中作为电子丸。 ;材料/方法:研究了超软硅胶基亚毫米薄钨片和铋片作为6-12 MeV的电子丸。平行板离子室测量是在瓦里安机上的固体水模体中进行的。测量了深度剂量特性,以优化所选电子治疗的表面剂量厚度为100%,并通过蒙特卡罗模拟验证。结果:硅胶钨和铋片产生显著的电子,从而增加了表面剂量。根据测量的深度剂量,我们的数据表明,0.14 mm、0.18 mm和0.2 mm的钨片和0.42 mm、0.18 mm和0.2 mm的铋片分别为6、9和12 MeV光束提供100%的表面剂量,除了表面剂量增加外,深度剂量没有明显变化。结论:这种新型的高z布状片状材料非常柔软,但具有高强度的金属丸状材料,可以完美地贴合任何皮肤轮廓。在不降低深度剂量特性的情况下,只需要0.2 mm厚的片材即可达到100%的表面剂量。这些材料可重复使用,是电子束治疗的理想材料。这项研究为设计最适合患者治疗的新型丸剂材料开辟了新的前沿。
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An investigation of high-Z material for bolus in electron beam therapy.

Highlight. Electron beam treatment often requires bolus to augment surface dose to nearly 100%. There are no optimum bolus materials and hence a high-Z based clothlike material is investigated to reduce air column in treatment that provides optimum surface dose. This material is well suited as it can be used multiple times and can be sanitized. Characteristics of W-Si material is provided.Purpose /Objective(s). Electron beams are frequently used for superficial tumors. However, due to electron beam characteristics the surface dose is 75-95% of the prescribed dose depending on beam energy thus requiring placement of bolus to augment surface dose. Various types of boluses are commonly used in clinics, each having it's own unique limitation. Most bolus devices do not conform to the skin contour and create airgaps that are known to produce dose perturbations creating hot and cold spots. A cloth-like high-Z materials; Tungsten, (Z = 74) and Bismuth, (Z = 83) impregnated in silicone gel is investigated for electron bolus.Materials/Methods. Super soft silicone-gel based submillimeter thin tungsten and bismuth sheets were investigated for bolus for 6-12 MeV. Parallel plate ion chamber measurements were performed in a solid water phantom on a Varian machine. Depth dose characteristics were measured to optimize the thickness for surface dose to be 100% for selected electron therapy and validated with Monte Carlo simulations.Results. Silicone-gel tungsten and bismuth sheets produce significant electrons thus increasing surface dose. Based on measured depth dose, our data showed that tungsten sheets of 0.14 mm, 0.18 mm and 0.2 mm and Bismuth sheets of 0.42 mm, 0.18 mm and 0.2 mm provide 100% surface dose for 6, 9 and 12 MeV beams, respectively without any significant changes in depth dose except increasing surface dose.Conclusions. The new high-Z clothlike sheets are extremely soft but high tensile metallic bolus materials that can fit flawlessly on any skin contour. Only 0.2 mm thick sheets are needed for 100% surface dose without degradation of the depth dose characteristics. These materials are reusable and ideal for bolus in electron beam treatment. This investigation opens a new frontier in designing new bolus materials optimum for patient treatment.

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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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