Jenny Zhen-Duan, Katia M Canenguez, Anna E Wilson, Yue Gu, Harshitha G Valluri, Alejandra D Chavez, M Austin Argentieri, Anna Boonin Schachter, Haotian Wu, Andrea A Baccarelli, Martha L Daviglus, Sylvia Wassertheil-Smoller, Erica T Warner, Alexandra E Shields
{"title":"西班牙/拉丁裔成人中hpa轴基因的宗教、灵性和DNA甲基化。","authors":"Jenny Zhen-Duan, Katia M Canenguez, Anna E Wilson, Yue Gu, Harshitha G Valluri, Alejandra D Chavez, M Austin Argentieri, Anna Boonin Schachter, Haotian Wu, Andrea A Baccarelli, Martha L Daviglus, Sylvia Wassertheil-Smoller, Erica T Warner, Alexandra E Shields","doi":"10.1080/17501911.2024.2442293","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.</p><p><strong>Methods: </strong>We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.</p><p><strong>Results: </strong>Among individuals with the <i>FKBP5</i> CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased <i>FKBP5</i> (CC genotype) methylation among immigrants.</p><p><strong>Conclusion: </strong>R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"155-166"},"PeriodicalIF":3.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812325/pdf/","citationCount":"0","resultStr":"{\"title\":\"Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.\",\"authors\":\"Jenny Zhen-Duan, Katia M Canenguez, Anna E Wilson, Yue Gu, Harshitha G Valluri, Alejandra D Chavez, M Austin Argentieri, Anna Boonin Schachter, Haotian Wu, Andrea A Baccarelli, Martha L Daviglus, Sylvia Wassertheil-Smoller, Erica T Warner, Alexandra E Shields\",\"doi\":\"10.1080/17501911.2024.2442293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.</p><p><strong>Methods: </strong>We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.</p><p><strong>Results: </strong>Among individuals with the <i>FKBP5</i> CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased <i>FKBP5</i> (CC genotype) methylation among immigrants.</p><p><strong>Conclusion: </strong>R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.</p>\",\"PeriodicalId\":11959,\"journal\":{\"name\":\"Epigenomics\",\"volume\":\" \",\"pages\":\"155-166\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812325/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epigenomics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17501911.2024.2442293\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17501911.2024.2442293","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/20 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.
Aim: Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.
Methods: We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.
Results: Among individuals with the FKBP5 CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased FKBP5 (CC genotype) methylation among immigrants.
Conclusion: R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
