{"title":"高压灭菌过程中Ziegler-Natta聚丙烯中两种硬脂酸清除剂向水中迁移行为的比较研究","authors":"Xin-Rao Zhang, Fu-Shan Wang, Xin Wang, Yan Gao, Hong-Xing Zhang, Zhi-Qin Liu, Jia-Chun Feng","doi":"10.1007/s10118-024-3213-6","DOIUrl":null,"url":null,"abstract":"<div><p>Although Ziegler-Natta (Z-N) polyolefins have been widely used as raw materials to produce pharmaceutical or food packaging, the migration of acid scavengers, an additive usually introduced in Z-N polyolefins, from the packaging to its contents has not been reported. In this work, the migration of the two most used acid scavengers, calcium stearate (CaSt<sub>2</sub>) and zinc stearate (ZnSt<sub>2</sub>), from a Z-N polypropylene random copolymer (PPR) into water during autoclaving at 121 °C were comparatively investigated. It was found that, for PPR plates containing 0.1 wt% CaSt<sub>2</sub> or ZnSt<sub>2</sub> (PPR-0.1CaSt<sub>2</sub>, PPR-0.1ZnSt<sub>2</sub>, respectively), the concentration of migrated calcium ion into water increased with autoclaving time, while that of zinc ion was much lower at same treatment durations and did not show a significant increase with treatment time. Interestingly, after removing all plates and acidification treatment, a considerable amount of stearic acid was detected in sterilized water for PPR-0.1ZnSt<sub>2</sub>, but no such significant stearic acid was detected in sterilized water for PPR-0.1CaSt<sub>2</sub>. Based on the structural evolution of the two soaps upon heating, possible mechanisms for the different migration behavior of CaSt<sub>2</sub> and ZnSt<sub>2</sub> from PPR into water during autoclaving treatment were proposed. Our results suggest that the migration issue of acid scavengers is worthy of attention in pharmaceutical packaging materials produced from Z-N polyolefins.</p></div>","PeriodicalId":517,"journal":{"name":"Chinese Journal of Polymer Science","volume":"43 1","pages":"90 - 100"},"PeriodicalIF":4.1000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment\",\"authors\":\"Xin-Rao Zhang, Fu-Shan Wang, Xin Wang, Yan Gao, Hong-Xing Zhang, Zhi-Qin Liu, Jia-Chun Feng\",\"doi\":\"10.1007/s10118-024-3213-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Although Ziegler-Natta (Z-N) polyolefins have been widely used as raw materials to produce pharmaceutical or food packaging, the migration of acid scavengers, an additive usually introduced in Z-N polyolefins, from the packaging to its contents has not been reported. In this work, the migration of the two most used acid scavengers, calcium stearate (CaSt<sub>2</sub>) and zinc stearate (ZnSt<sub>2</sub>), from a Z-N polypropylene random copolymer (PPR) into water during autoclaving at 121 °C were comparatively investigated. It was found that, for PPR plates containing 0.1 wt% CaSt<sub>2</sub> or ZnSt<sub>2</sub> (PPR-0.1CaSt<sub>2</sub>, PPR-0.1ZnSt<sub>2</sub>, respectively), the concentration of migrated calcium ion into water increased with autoclaving time, while that of zinc ion was much lower at same treatment durations and did not show a significant increase with treatment time. Interestingly, after removing all plates and acidification treatment, a considerable amount of stearic acid was detected in sterilized water for PPR-0.1ZnSt<sub>2</sub>, but no such significant stearic acid was detected in sterilized water for PPR-0.1CaSt<sub>2</sub>. Based on the structural evolution of the two soaps upon heating, possible mechanisms for the different migration behavior of CaSt<sub>2</sub> and ZnSt<sub>2</sub> from PPR into water during autoclaving treatment were proposed. Our results suggest that the migration issue of acid scavengers is worthy of attention in pharmaceutical packaging materials produced from Z-N polyolefins.</p></div>\",\"PeriodicalId\":517,\"journal\":{\"name\":\"Chinese Journal of Polymer Science\",\"volume\":\"43 1\",\"pages\":\"90 - 100\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Polymer Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10118-024-3213-6\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10118-024-3213-6","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment
Although Ziegler-Natta (Z-N) polyolefins have been widely used as raw materials to produce pharmaceutical or food packaging, the migration of acid scavengers, an additive usually introduced in Z-N polyolefins, from the packaging to its contents has not been reported. In this work, the migration of the two most used acid scavengers, calcium stearate (CaSt2) and zinc stearate (ZnSt2), from a Z-N polypropylene random copolymer (PPR) into water during autoclaving at 121 °C were comparatively investigated. It was found that, for PPR plates containing 0.1 wt% CaSt2 or ZnSt2 (PPR-0.1CaSt2, PPR-0.1ZnSt2, respectively), the concentration of migrated calcium ion into water increased with autoclaving time, while that of zinc ion was much lower at same treatment durations and did not show a significant increase with treatment time. Interestingly, after removing all plates and acidification treatment, a considerable amount of stearic acid was detected in sterilized water for PPR-0.1ZnSt2, but no such significant stearic acid was detected in sterilized water for PPR-0.1CaSt2. Based on the structural evolution of the two soaps upon heating, possible mechanisms for the different migration behavior of CaSt2 and ZnSt2 from PPR into water during autoclaving treatment were proposed. Our results suggest that the migration issue of acid scavengers is worthy of attention in pharmaceutical packaging materials produced from Z-N polyolefins.
期刊介绍：
Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985.
CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.
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