Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates

The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches that have enabled studies at a level of detail – and ease – that were not previously possible. Yet, significant deficiencies in our understanding of biomolecular function remain and new challenges must be overcome to go beyond static pictures towards a description of function in terms of structural dynamics. Solution Nuclear Magnetic Resonance (NMR) spectroscopy has emerged as a powerful technique for atomic resolution studies of the dynamics of a wide range of biomolecules, including molecular machines and the components of phase-separated condensates. Here we highlight some of the very recent advances in these areas that have been driven by NMR.