sting激活聚合物促进mRNA疫苗的淋巴传递以增强癌症免疫治疗（Adv. Mater. 10/2025）

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Materials Pub Date : 2025-03-12 DOI:10.1002/adma.202570078

Miao Zhang, Yongling Wang, Benhao Li, Bowei Yang, Mengyao Zhao, Bingyu Li, Jianping Liu, Yaxin Hu, Zhaoming Wu, Yenhui Ong, Xiaolin Han, Lingwen Ding, Kongfu Zhu, Jianwei Li, Min Luo, Shengqi Chen, Ling Peng, Longjiang Zhang, Xiaoyuan Chen, Qianqian Ni

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摘要

癌症疫苗在文章编号2412654中，倪倩倩、陈晓媛、张龙江及其团队介绍了一种新型STING激活聚合物（PD）来增强mRNA疫苗的免疫原性。通过在脂质纳米粒子中加入PD聚合物，得到的载体（PD LNP）改善了mRNA癌症疫苗的淋巴传递和免疫激活，证明了PD LNPs在癌症免疫治疗中的巨大潜力。

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STING-Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy (Adv. Mater. 10/2025)

Cancer Vaccine

In article number 2412654, Qianqian Ni, Xiaoyuan Chen, Longjiang Zhang, and their team present a novel STING-activating polymer (PD) to enhance mRNA vaccine immunogenicity. By incorporating PD polymer into lipid nanoparticle, the resulted vehicle (PD LNP) improved lymphatic delivery and immune activation of mRNA cancer vaccine, demonstrating the promising potential of PD LNPs for cancer immunotherapy.

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.