高渗盐水/右旋糖酐与乳酸林格治疗脱水猪出血的比较。

Circulatory shock Pub Date : 1994-12-01
M D McKirnan, R L Williams, U Limjoco, J Ragland, C G Gray
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引用次数: 0

摘要

为了确定低容量复苏对脱水受试者的效果,在37%血容量出血前脱水48小时的清醒猪中,比较7.5%高渗生理盐水/6%葡聚糖70 (HSD)和乳酸林格(LR)治疗。随机分配到治疗组的猪在出血60分钟后用等量钠负荷HSD (4 ml/kg)或LR (33.3 ml/kg)进行复苏。脱水导致体重减少7-8%。恢复180分钟后,HSD的死亡率为1/13 (7.7%),LR的死亡率为1/11(9.1%),而脱水和未经治疗的对照组(DC)的死亡率为4/8(50%)。在出血和复苏后的恢复期,HSD和LR溶液引起相似的心率、心输出量、动脉压和氧转运反应。HSD在扩大脱水出血猪血浆容量方面与LR一样有效。血清化学没有证据表明HSD治疗有持续的全身毒性。这些发现支持小容量HSD复苏失血性休克在中度脱水受试者。
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Hypertonic saline/dextran versus lactated Ringer's treatment for hemorrhage in dehydrated swine.

To determine the efficacy of low-volume resuscitation in dehydrated subjects, 7.5% hypertonic saline/6% dextran 70 (HSD) and lactated Ringer's (LR) treatments were compared in conscious pigs dehydrated for 48 hr prior to a 37% blood volume hemorrhage. Pigs randomized to treatment were resuscitated with equivalent sodium loads of either HSD (4 ml/kg) or LR (33.3 ml/kg) following the 60-min hemorrhage. Dehydration resulted in a 7-8% body weight loss. Mortality through 180 min of recovery was 1/13 (7.7%) for HSD, 1/11 (9.1%) for LR, and 4/8 (50%) for a group of dehydrated and untreated controls (DC). HSD and LR solutions elicited similar heart rate, cardiac output, arterial pressure, and oxygen transport responses in the recovery period following hemorrhage and resuscitation. HSD was as effective as LR in expanding plasma volume in dehydrated hemorrhaged pigs. Serum chemistries provided no evidence for a sustained systemic toxicity from HSD treatment. These findings support low-volume HSD resuscitation of hemorrhagic shock in moderately dehydrated subjects.

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