人体对细菌内毒素的反应。

Circulatory shock Pub Date : 1994-07-01
R Burrell
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引用次数: 0

摘要

关于人体对细菌内毒素的反应的文献,特别是对纯化的脂多糖衍生物,已经进行了严格的审查和总结。选择供审查的论文是那些报告了在正常健康状态下接受规定剂量静脉注射或气溶胶吸入物质的人类受试者的研究。重点放在心血管、肺、代谢和炎症参数上。这里详细的信息可以应用于理解由这种高度炎症和普遍存在的物质引起的自发性临床疾病的人类后果的病理生理学。
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Human responses to bacterial endotoxin.

The literature concerning human responses to bacterial endotoxin, in particular to the purified lipopolysaccharide derivative, has been critically reviewed and summarized. Papers selected for review are those that reported studies of human subjects in a normal state of health administered defined doses of either intravenous or aerosol inhaled material. Emphasis was placed on cardiovascular, pulmonary, metabolic, and inflammatory parameters. The information detailed here can be applied to understanding the pathophysiology of human consequences to spontaneous, clinical diseases induced by this highly inflammatory and ubiquitous substance.

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Comparison of binding specificity and the function of two human IgM anti-lipid A monoclonal antibodies. Hypertonic saline/dextran versus lactated Ringer's treatment for hemorrhage in dehydrated swine. Lysozyme regulates LPS-induced interleukin-6 release in mice. Liver oxygen uptake dependence and mitochondrial function in septic rats. Efficacy of continuous arteriovenous hemofiltration in endotoxic shock.
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