甲基强的松龙对大鼠肺和循环血液中性粒细胞脂多糖诱导的超氧化物产生的体内影响。

Circulatory shock Pub Date : 1994-03-01
C Tsuji, S Shioya
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引用次数: 0

摘要

研究了甲基强的松龙对大鼠静脉注射脂多糖后肺和循环血液中性粒细胞产生超氧化物的影响。脂多糖注射增加了两种中性粒细胞的超氧化物产生,甲基强的松龙预处理抑制了这种增加。甲基强的松龙对肺中性粒细胞的抑制作用大于对循环血液中性粒细胞的抑制作用。甲基强的松龙也能阻止脂多糖诱导的肺血管通透性增加,但不能抑制肺内中性粒细胞的积累。这些结果表明,抑制超氧化物的产生可能是甲基强的松龙预防内毒素诱导的肺损伤的一种机制。
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In vivo effect of methylprednisolone on lipopolysaccharide-induced superoxide production by pulmonary and circulating blood neutrophils in rats.

The effect of methylprednisolone on superoxide production by pulmonary and circulating blood neutrophils was investigated in rats after the intravenous injection of lipopolysaccharide. Superoxide production by both types of neutrophils was increased by lipopolysaccharide injection, and pretreatment with methylprednisolone inhibited this increase. The inhibitory effect of methylprednisolone on pulmonary neutrophils was greater than that on circulating blood neutrophils. Methylprednisolone also prevented the increase in pulmonary vascular permeability induced by lipopolysaccharide, but failed to inhibit intrapulmonary neutrophil accumulation. These results suggest that the suppression of superoxide production may be one mechanism by which methylprednisolone prevents endotoxin-induced lung damage.

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