[睾酮对大鼠前列腺腹侧组织VEGF及FLK-1蛋白表达的影响]。

Xiaodong Liu, Qiang Dong, Yiping Lu, Bangliang Xiao, Xiuying Yang, Yuru Yang
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引用次数: 0

摘要

目的:探讨睾酮对大鼠前列腺腹侧组织VEGF及FLK-1蛋白表达的影响。方法:SD大鼠去势,7 d后注射不同剂量的睾酮。HE染色观察组织学变化,免疫组化检测VEGF、FLK-1蛋白表达。结果:正常前列腺腹侧部有不同生长形式的上皮。去势组生长活性上皮和血管内皮中VEGF、FLK-1蛋白表达阳性;前列腺重量降低(P < 0.05);组织学表现为上皮萎缩,前列腺上皮中VEGF、FLK-1蛋白表达显著降低(P < 0.05)。结果发现睾酮注射对前列腺增生的刺激是渐进性的,组织学变化为上皮进行性增生。前列腺上皮中VEGF、FLK-1蛋白表达逐渐升高(P < 0.05)。结论:睾酮可能通过上调VEGF和FLK-1蛋白表达来促进前列腺生长。
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[Effects of testosterone on VEGF and FLK-1 protein expression in the ventral prostate of rat].

Objective: To investigate the effects of testosterone on VEGF and FLK-1 protein expression in the ventral prostate of Rat.

Method: SD rats were castrated, and 7 days later they were injected with different doses of testosterone. The histological changes were observed with the use of HE staining, and the protein expression of VEGF, FLK-1 were measured by immunohistochemical test.

Results: In the normal ventral prostate, different growth forms of epithelium were observed. In the castrated group, the proteins of VEGF, FLK-1 were positive in growth active epithelium and vascular endothelium; the weight of prostate decreased (P < 0.05); the histological appearance was epithelial atrophy, and there was significantly decreased protein expression of VEGF, FLK-1 in the prostatic epithelium (P < 0.05). It was found that testosterone injection stimulated prostatic hyperplasia gradually The histological changes were epithelial progressive proliferation. And a gradually increased protein expression of VEGF, FLK-1 in the prostatic epithelium was detected (P < 0.05).

Conclusion: Testosterone can stimulate prostatic growth probably by upregulating the protein expression of VEGF and FLK-1.

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