Eugene D. Weinberg, Robert Chernin, John H. Billman
{"title":"金属结合与苯乙基双胍生物活性的关系","authors":"Eugene D. Weinberg, Robert Chernin, John H. Billman","doi":"10.1002/jps.3030490710","DOIUrl":null,"url":null,"abstract":"<div><p>Phenethylbiguanide has been found to form metal complexes with divalent copper and nickel; on the basis of infrared absorption spectra and on theoretical considerations, a revised structure for the metal complexes of biguanides is proposed. Antimicrobial activities of phenethylbiguanide are not affected by divalent copper and nickel but are significantly depressed by iron. The relationship of these findings to the biological mechanisms of action of the compound is discussed.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 7","pages":"Pages 441-444"},"PeriodicalIF":0.0000,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490710","citationCount":"3","resultStr":"{\"title\":\"The Relationship of Metal Binding to the Biological Activities of Phenethylbiguanide*\",\"authors\":\"Eugene D. Weinberg, Robert Chernin, John H. Billman\",\"doi\":\"10.1002/jps.3030490710\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Phenethylbiguanide has been found to form metal complexes with divalent copper and nickel; on the basis of infrared absorption spectra and on theoretical considerations, a revised structure for the metal complexes of biguanides is proposed. Antimicrobial activities of phenethylbiguanide are not affected by divalent copper and nickel but are significantly depressed by iron. The relationship of these findings to the biological mechanisms of action of the compound is discussed.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 7\",\"pages\":\"Pages 441-444\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490710\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315362569\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315362569","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Relationship of Metal Binding to the Biological Activities of Phenethylbiguanide*
Phenethylbiguanide has been found to form metal complexes with divalent copper and nickel; on the basis of infrared absorption spectra and on theoretical considerations, a revised structure for the metal complexes of biguanides is proposed. Antimicrobial activities of phenethylbiguanide are not affected by divalent copper and nickel but are significantly depressed by iron. The relationship of these findings to the biological mechanisms of action of the compound is discussed.
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