通过基因组学提高牛对BRD的抗性。

IF 4.3 2区 农林科学 Q1 VETERINARY SCIENCES Animal Health Research Reviews Pub Date : 2020-12-01 DOI:10.1017/S1466252320000171
Kristen L Parker Gaddis
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引用次数: 2

摘要

牛呼吸道疾病(BRD)对乳制品行业具有相当大的经济重要性,特别是在幼畜中。一些研究表明,BRD具有显著的遗传成分,遗传力从0.04到0.22不等,可用于选择更具抗性的动物。利用现有的基因组数据,可以在动物生命的早期做出更准确的基因预测。基因组数据的可用性并不否定高质量表型的必要性,在这种情况下,BRD发病率的记录。有证据表明,通过使用生产者记录的健康信息进行遗传选择是可能的。目前,国家乳制品合作数据库中关于呼吸道疾病的记录很少。现有的管道可以使这些数据从养殖场生产者记录的事件流向用于遗传评估的国家数据库。还可以通过扩大目前使用的终止代码收集更多数据,并与直接健康事件的记录一起使用。有可能在国家一级选择具有改良BRD抗性的动物;然而,额外表型的收集仍然是一个重大障碍。
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Improving resistance of cattle to BRD through genomics.

Bovine respiratory disease (BRD) is of considerable economic importance to the dairy industry, specifically among young animals. Several studies have demonstrated that BRD has a significant genetic component, with heritabilities ranging from 0.04 up to 0.22, which could be utilized to select more resistant animals. Taking advantage of available genomic data will allow more accurate genetic predictions to be made earlier in an animal's life. The availability of genomic data does not negate the necessity of quality phenotypes, in this case, records of BRD incidence. Evidence has shown that genetic selection is possible through the use of producer-recorded health information. The national dairy cooperator database currently has minimal records on respiratory problems. There is an existing pipeline for these data to flow from events recorded by producers on the farm to the national database used for genetic evaluation. Additional data could also be collected through the expansion of currently utilized termination codes and used in conjunction with the records of direct health events. Selection for animals with improved BRD resistance is possible at the national level; however, collection of additional phenotypes remains a significant hurdle.

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来源期刊
Animal Health Research Reviews
Animal Health Research Reviews VETERINARY SCIENCES-
CiteScore
6.70
自引率
0.00%
发文量
8
期刊介绍: Animal Health Research Reviews provides an international forum for the publication of reviews and commentaries on all aspects of animal health. Papers include in-depth analyses and broader overviews of all facets of health and science in both domestic and wild animals. Major subject areas include physiology and pharmacology, parasitology, bacteriology, food and environmental safety, epidemiology and virology. The journal is of interest to researchers involved in animal health, parasitologists, food safety experts and academics interested in all aspects of animal production and welfare.
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