Moira K Christoudias, Abigail E Collett, Tari S Stull, Edward J Gracely, Thomas G Frazier, Andrea V Barrio
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引用次数: 17
摘要
美国放射肿瘤学学会(ASTRO)共识声明(CS)为保乳手术后患者选择加速部分乳房照射(APBI)提供了指南。本研究的目的是评估基于ASTRO CS分组的复发率。一项针对238例接受球囊APBI近距离放射治疗的早期乳腺癌患者的研究表明,4年精算同侧乳腺癌复发率(IBTR)为5.1%。“适宜”、“警示”和“不适宜”ASTRO类别的4年精算IBTR率无显著差异(分别为0%、7.2%和4.3%)。, p = 0.28)。ER阴性肿瘤的IBTR率高于ER阳性肿瘤。ASTRO分组不能很好地预测患者的预后。需要进一步的研究来评估个体临床病理特征,以确定APBI在高危患者中的安全性。
Are the American Society for Radiation Oncology guidelines accurate predictors of recurrence in early stage breast cancer patients treated with balloon-based brachytherapy?
The American Society for Radiation Oncology (ASTRO) consensus statement (CS) provides guidelines for patient selection for accelerated partial breast irradiation (APBI) following breast conserving surgery. The purpose of this study was to evaluate recurrence rates based on ASTRO CS groupings. A single institution review of 238 early stage breast cancer patients treated with balloon-based APBI via balloon based brachytherapy demonstrated a 4-year actuarial ipsilateral breast tumor recurrence (IBTR) rate of 5.1%. There were no significant differences in the 4-year actuarial IBTR rates between the "suitable," "cautionary," and "unsuitable" ASTRO categories (0%, 7.2%, and 4.3%, resp., P = 0.28). ER negative tumors had higher rates of IBTR than ER positive tumors. The ASTRO groupings are poor predictors of patient outcomes. Further studies evaluating individual clinicopathologic features are needed to determine the safety of APBI in higher risk patients.
期刊介绍:
International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.