偶然发现肺癌的临床特点及预后。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2015-01-01 Epub Date: 2015-02-03 DOI:10.1155/2015/287604
S Quadrelli, G Lyons, H Colt, D Chimondeguy, A Buero
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引用次数: 0

摘要

目的:评价偶然发现的肺癌和有症状的肺癌的临床特点和预后。材料和方法:我们设计了一项回顾性研究,包括所有接受肺切除术的非小细胞肺癌患者。根据无症状诊断(ASX) -偶然诊断-或有症状诊断时是否存在癌症相关症状,将患者分为两组。结果:593例患者中,ASX 320例(53.9%)。其中71.8%是通过胸片诊断的。ASX组患者年龄较大(P = 0.007),既往恶性肿瘤患病率较高(P = 0.002),更频繁地表现为孤立结节(P < 0.001),更可能患有早期疾病和较小的癌症(P = 0.0001)。近10年意外检出率较高(P = 0.008)。ASX患者总体5年生存率较高(P = 0.001)。病理分期iib - iv期的中位生存时间差异无统计学意义。结论:意外发现的非小细胞肺癌即使在不吸烟者中也不罕见。常见于吸烟者和既往有恶性肿瘤病史者。意外诊断组死亡率较低,但较好的生存率与早期发病人数较多有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Clinical characteristics and prognosis of incidentally detected lung cancers.

Objective: To evaluate clinical characteristics and outcomes in incidentally detected lung cancer and in symptomatic lung cancer.

Material and methods: We designed a retrospective study including all patients undergoing pulmonary resection with a curative intention for NSCLC. They were classified into two groups according to the presence or absence of cancer-related symptoms at diagnosis in asymptomatic (ASX)—incidental diagnosis—or symptomatic.

Results: Of the 593 patients, 320 (53.9%) were ASX. In 71.8% of these, diagnosis was made by chest X-ray. Patients in the ASX group were older (P = 0.007), had a higher prevalence of previous malignancy (P = 0.002), presented as a solitary nodule more frequently (P < 0.001), and were more likely to have earlier-stage disease and smaller cancers (P = 0.0001). A higher prevalence of incidental detection was observed in the last ten years (P = 0.008). Overall 5-year survival was higher for ASX (P = 0.001). Median survival times in pathological stages IIIB-IV were not significantly different.

Conclusion: Incidental finding of NSCLC is not uncommon even among nonsmokers. It occurred frequently in smokers and in those with history of previous malignancy. Mortality of incidental diagnosis group was lower, but the better survival was related to the greater number of patients with earlier-stage disease.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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