胰腺癌甲状腺功能减退:外源性甲状腺激素在肿瘤侵袭中的作用——初步观察。

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI:10.1155/2016/2454989
Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat
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引用次数: 19

摘要

根据流行病学研究,约4.4%的美国普通老年人患有明显的甲状腺功能减退症,每天需要补充甲状腺激素。我们的胰腺癌患者甲状腺功能减退的患病率要高得多,为14.1%。回顾性分析了2005年至2012年在费城托马斯杰斐逊大学医院接受胰十二指肠切除术(Whipple手术)或远端胰切除术和脾切除术(DPS)的患者。甲状腺功能减退的诊断与临床病理参数相关,包括肿瘤分期、分级和生存。为了进一步了解甲状腺激素如何影响胰腺癌行为,我们对胰腺癌细胞系MiaPaCa-2和AsPC-1进行了功能研究,包括伤口诱导的细胞迁移、增殖和侵袭。我们发现,服用外源性甲状腺激素的甲状腺功能减退患者发生神经周围侵犯的可能性是服用外源性甲状腺激素的患者的3倍以上,发生高T期、淋巴结转移和总体预后不良期的可能性是服用外源性甲状腺激素的患者的2倍左右(P < 0.05)。胰腺癌细胞系研究表明,外源性甲状腺激素治疗增加了细胞的增殖、迁移和侵袭(P < 0.05)。我们得出结论,外源性甲状腺激素可能有助于胰腺癌的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations.

According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival. To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage (P < 0.05). Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion (P < 0.05). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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