晚期低度或中度胃肠胰神经内分泌肿瘤的治疗选择:近期文献综述。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2017-01-01 Epub Date: 2017-05-16 DOI:10.1155/2017/6424812
Vladimir Neychev, Electron Kebebew
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引用次数: 16

摘要

在过去的几十年里,我们对胃肠道和胰腺神经内分泌肿瘤(NETs)的生物学、遗传学和自然史的了解有了很大的提高,可用的治疗选择范围也在迅速扩大。转移性低或中级NETs患者的管理已经通过新的治疗策略的发展发生了革命性的变化,如依维莫司和舒尼替尼的分子靶向治疗、生长抑素类似物、色氨酸羟化酶抑制剂和肽受体放射性核素治疗,这些治疗方法可以单独使用,也可以作为多模式方法,有或没有手术。为了进一步定义和澄清这一患者群体的效用、适当性和可用治疗的顺序,将需要更多的高水平证据;然而,精心设计的随机III期临床试验的数据正在迅速积累,这将进一步刺激新的管理策略的发展。因此,重要的是彻底审查新出现的证据,并在频繁更新中报告主要发现,这将扩大我们的知识,并有助于更好地理解、表征和管理先进的网络。
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Management Options for Advanced Low or Intermediate Grade Gastroenteropancreatic Neuroendocrine Tumors: Review of Recent Literature.

Our understanding of the biology, genetics, and natural history of neuroendocrine tumors (NETs) of the gastrointestinal tract and pancreas has improved considerably in the last several decades and the spectrum of available therapeutic options is rapidly expanding. The management of patients with metastatic low or intermediate grade NETs has been revolutionized by the development of new treatment strategies such as molecular targeting therapies with everolimus and sunitinib, somatostatin analogs, tryptophan hydroxylase inhibitors, and peptide receptor radionuclide therapy that can be used alone or as a multimodal approach with or without surgery. To further define and clarify the utility, appropriateness, and the sequence of the growing list of available therapies for this patient population will require more high level evidence; however, data from well-designed randomized phase III clinical trials is rapidly accumulating that will further stimulate development of new management strategies. It is therefore important to thoroughly review emerging evidence and report major findings in frequent updates, which will expand our knowledge and contribute to a better understanding, characterization, and management of advanced NETs.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
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