卵巢颗粒细胞瘤31例临床分析及文献复习。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2018-03-29 eCollection Date: 2018-01-01 DOI:10.1155/2018/4547892
Manel Dridi, Nesrine Chraiet, Rim Batti, Mouna Ayadi, Amina Mokrani, Khedija Meddeb, Yosra Yahiaoui, Henda Raies, Amel Mezlini
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引用次数: 31

摘要

背景:成人颗粒细胞瘤(agct)是最常见的性索间质肿瘤。与卵巢上皮性肿瘤不同,它们发生在年轻女性中,通常在早期被发现。本研究的目的是报告AGCT患者的临床和病理特征,并确定预后因素。方法:回顾性分析Salah Azaïz研究所1995年至2010年间治疗的所有agct病例。采用Kaplan-Meier统计方法评估无复发生存期和总生存期。结果:最终队列包括31例AGCT患者。平均年龄53岁(35 ~ 73岁)。患者主要表现为腹部肿块和/或疼痛(61%,n = 19)。肿瘤平均大小为20cm。大多数患者为I期疾病(61%,n = 19)。3例IV期患者中2例出现肝转移。有丝分裂指数低的病例占45% (n = 14)。手术治疗在几乎所有病例(90%,n = 28)中都是最佳的。中位随访时间为14年(1 ~ 184个月)。10例患者复发(32%),中位RFS为8.4年(6.8-9.9年)。平均总生存期为13年(11-15年)。单变量分析显示,I期疾病和低至中等有丝分裂指数与较好的预后相关。, p = 0.05和p = 0.02),但不是独立的预后因素。结论:gct具有较长的自然病程,常见的晚期复发。因此,建议长期积极随访。在突尼斯患者中,肝转移比西方患者更常见。预后良好,诊断时的初始分期是一个重要的预后因素。
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Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.

Background: Adult granulosa cell tumors (AGCTs) are the most common sex cord-stromal tumors. Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage. The aim of this study was to report the clinical and pathological characteristics of AGCT patients and to identify the prognostic factors.

Methods: All cases of AGCTs, treated at Salah Azaïz Institute between 1995 and 2010, were retrospectively included. Kaplan-Meier's statistical method was used to assess the relapse-free survival and the overall survival.

Results: The final cohort included 31 patients with AGCT. The mean age was 53 years (35-73 years). Patients mainly presented with abdominal mass and/or pain (61%, n = 19). Mean tumor size was 20 cm. The majority of patients had a stage I disease (61%,  n = 19). Two among 3 patients with stage IV disease had liver metastasis. Mitotic index was low in 45% of cases (n = 14). Surgical treatment was optimal in almost all cases (90%, n = 28). The median follow-up time was 14 years (1-184 months). Ten patients relapsed (32%) with a median RFS of 8.4 years (6.8-9.9 years). Mean overall survival was 13 years (11-15 years). Stage I disease and low-to-intermediate mitotic index were associated with a better prognosis in univariate analysis (resp., p = 0.05 and p = 0.02) but were not independent prognostic factors.

Conclusion: GCTs have a long natural history with common late relapses. Hence, long active follow-up is recommended. In Tunisian patients, hepatic metastases were more frequent than occidental series. The prognosis remains good and initial staging at diagnosis is an important prognostic factor.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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