硬纤维瘤的治疗:30例回顾性研究。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2020-07-18 eCollection Date: 2020-01-01 DOI:10.1155/2020/9197216
Yosr Zenzri, Yosra Yahyaoui, Lamia Charfi, Zahra Ghodhbani, Feryel Letaief, Mouna Ayadi, Amel Mezlini
{"title":"硬纤维瘤的治疗:30例回顾性研究。","authors":"Yosr Zenzri,&nbsp;Yosra Yahyaoui,&nbsp;Lamia Charfi,&nbsp;Zahra Ghodhbani,&nbsp;Feryel Letaief,&nbsp;Mouna Ayadi,&nbsp;Amel Mezlini","doi":"10.1155/2020/9197216","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Desmoid tumor also called aggressive fibromatosis is a rare type of benign tumor. It is a mesenchymal malignancy without metastatic potential. The standard management is resection, but other options including observation may be discussed. Desmoid-type fibromatosis may occur throughout the body, but the abdominal wall is the most common site. The aim of our study was to assess the clinicoepidemiological profile, prognostic factors, and treatment outcome of desmoid tumors.</p><p><strong>Methods: </strong>A monocentric retrospective study was conducted over a period of 19 years between February 2000 and November 2019 at the oncology department of Salah Azaïz Institute. Our study concerns 30 patients with desmoid tumor. All data regarding patients were obtained from the medical record.</p><p><strong>Results: </strong>Thirty patients were included. The median age was 35 years with a female predominance (sex ratio = 0.07). A palpable mass was the most common complaint (<i>n</i> = 27). Median tumor size was 5 cm. The principal site of involvement was the abdominal wall (<i>n</i> = 14). Surgery was performed in 27 patients. The histopathology reports listed 14 (52%) cases with negative margins and 13 (48%) cases with positive margins. Radiation therapy was performed in 2 patients. One patient received tamoxifen. Local recurrence occurred in 11 patients. Two patients died of their desmoid tumor. Abdominal wall tumors have less risk of recurrence compared with other sites (<i>p</i>=0.047). Macroscopic margin involvement (R2) was the only prognostic factor influencing disease-free-survival (<i>p</i>=0.034).</p><p><strong>Conclusion: </strong>Desmoid tumors are aggressive tumors with a tendency for local recurrence. Abdominal wall tumors have less risk of recurrence. Macroscopic margin involvement was the only prognostic factor that affects disease-free-survival.</p>","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2020-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9197216","citationCount":"7","resultStr":"{\"title\":\"The Management of Desmoid Tumors: A Retrospective Study of 30 Cases.\",\"authors\":\"Yosr Zenzri,&nbsp;Yosra Yahyaoui,&nbsp;Lamia Charfi,&nbsp;Zahra Ghodhbani,&nbsp;Feryel Letaief,&nbsp;Mouna Ayadi,&nbsp;Amel Mezlini\",\"doi\":\"10.1155/2020/9197216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Desmoid tumor also called aggressive fibromatosis is a rare type of benign tumor. It is a mesenchymal malignancy without metastatic potential. The standard management is resection, but other options including observation may be discussed. Desmoid-type fibromatosis may occur throughout the body, but the abdominal wall is the most common site. The aim of our study was to assess the clinicoepidemiological profile, prognostic factors, and treatment outcome of desmoid tumors.</p><p><strong>Methods: </strong>A monocentric retrospective study was conducted over a period of 19 years between February 2000 and November 2019 at the oncology department of Salah Azaïz Institute. Our study concerns 30 patients with desmoid tumor. All data regarding patients were obtained from the medical record.</p><p><strong>Results: </strong>Thirty patients were included. The median age was 35 years with a female predominance (sex ratio = 0.07). A palpable mass was the most common complaint (<i>n</i> = 27). Median tumor size was 5 cm. The principal site of involvement was the abdominal wall (<i>n</i> = 14). Surgery was performed in 27 patients. The histopathology reports listed 14 (52%) cases with negative margins and 13 (48%) cases with positive margins. Radiation therapy was performed in 2 patients. One patient received tamoxifen. Local recurrence occurred in 11 patients. Two patients died of their desmoid tumor. Abdominal wall tumors have less risk of recurrence compared with other sites (<i>p</i>=0.047). Macroscopic margin involvement (R2) was the only prognostic factor influencing disease-free-survival (<i>p</i>=0.034).</p><p><strong>Conclusion: </strong>Desmoid tumors are aggressive tumors with a tendency for local recurrence. Abdominal wall tumors have less risk of recurrence. Macroscopic margin involvement was the only prognostic factor that affects disease-free-survival.</p>\",\"PeriodicalId\":45960,\"journal\":{\"name\":\"International Journal of Surgical Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2020-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2020/9197216\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Surgical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2020/9197216\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/9197216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 7

摘要

目的:硬纤维瘤又称侵袭性纤维瘤病,是一种罕见的良性肿瘤。它是一种间充质恶性肿瘤,无转移潜能。标准的治疗方法是切除,但也可以讨论其他治疗方法,包括观察。纤维瘤病可以发生在全身,但最常见的部位是腹壁。本研究的目的是评估硬纤维瘤的临床流行病学特征、预后因素和治疗结果。方法:2000年2月至2019年11月在Salah Azaïz研究所肿瘤科进行了一项为期19年的单中心回顾性研究。本研究涉及30例硬纤维瘤患者。有关患者的所有数据均来自医疗记录。结果:纳入30例患者。年龄中位数为35岁,女性居多(性别比= 0.07)。可触及肿块是最常见的主诉(n = 27)。中位肿瘤大小为5cm。主要受累部位为腹壁(n = 14)。27例患者行手术治疗。组织病理学报告列出了14例(52%)阴性边缘和13例(48%)阳性边缘。2例患者行放射治疗。一名患者接受了他莫昔芬治疗。局部复发11例。2例患者死于硬纤维瘤。腹壁肿瘤复发风险较其他部位低(p=0.047)。肉眼切缘受累(R2)是影响无病生存的唯一预后因素(p=0.034)。结论:硬纤维瘤是侵袭性肿瘤,有局部复发的倾向。腹壁肿瘤复发的风险较小。肉眼可见的切缘受累是影响无病生存的唯一预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The Management of Desmoid Tumors: A Retrospective Study of 30 Cases.

Objectives: Desmoid tumor also called aggressive fibromatosis is a rare type of benign tumor. It is a mesenchymal malignancy without metastatic potential. The standard management is resection, but other options including observation may be discussed. Desmoid-type fibromatosis may occur throughout the body, but the abdominal wall is the most common site. The aim of our study was to assess the clinicoepidemiological profile, prognostic factors, and treatment outcome of desmoid tumors.

Methods: A monocentric retrospective study was conducted over a period of 19 years between February 2000 and November 2019 at the oncology department of Salah Azaïz Institute. Our study concerns 30 patients with desmoid tumor. All data regarding patients were obtained from the medical record.

Results: Thirty patients were included. The median age was 35 years with a female predominance (sex ratio = 0.07). A palpable mass was the most common complaint (n = 27). Median tumor size was 5 cm. The principal site of involvement was the abdominal wall (n = 14). Surgery was performed in 27 patients. The histopathology reports listed 14 (52%) cases with negative margins and 13 (48%) cases with positive margins. Radiation therapy was performed in 2 patients. One patient received tamoxifen. Local recurrence occurred in 11 patients. Two patients died of their desmoid tumor. Abdominal wall tumors have less risk of recurrence compared with other sites (p=0.047). Macroscopic margin involvement (R2) was the only prognostic factor influencing disease-free-survival (p=0.034).

Conclusion: Desmoid tumors are aggressive tumors with a tendency for local recurrence. Abdominal wall tumors have less risk of recurrence. Macroscopic margin involvement was the only prognostic factor that affects disease-free-survival.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
The Sublingual Gland Flap for Oral Reconstruction: Insights From a Single Institutional Experience. Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer. Risk Factors for Early Postoperative Morbidity and Mortality following Extremity Metastatic Pathologic or Impending Fracture Fixation. Differentiated Thyroid Carcinoma Long-Term Prognostic Factors. Risk Factors of Oral Squamous Cell Carcinoma with Special Emphasis on Areca Nut Usage and Its Association with Clinicopathological Parameters and Recurrence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1